[2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Base Information

Chemical Name:[2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE
CAS No.:912762-88-0
Molecular Formula:C13H20ClFN2O2
Molecular Weight:254.304
Hs Code.:2924299090
Mol file:912762-88-0.mol

Synonyms:[2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Suppliers and Price of [2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of [2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property:

Vapor Pressure:7.1E-06mmHg at 25°C
Boiling Point:376.7°C at 760 mmHg
PKA:12.27±0.46(Predicted)
Flash Point:181.6°C
PSA：64.35000
Density:1.126g/cm³
LogP:3.44140

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

There total 7 articles about [2-AMINO-2-(4-FLUORO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1246366-47-1
C₂₀H₂₅FN₂O₂

: 912762-88-0
rac-tert-butyl [2-amino-2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: With 20 % Pd(OH)2/C; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2010.07.121

Reference yield: 85.0%

: 912762-88-0
rac-tert-butyl [2-amino-2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: With methylamine; In water; at 60 ℃;

Reference yield:

: 877319-43-2
tert-butyl (2-(4-fluorophenyl)-2-oxoethyl)carbamate

: 912762-88-0
rac-tert-butyl [2-amino-2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; pyridine / ethanol / 3 h

2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 2068.65 Torr

With pyridine; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; In methanol; ethanol;
DOI:10.1016/j.bmcl.2016.03.043