5-BroMo-1-isopropylbenzoiMidazole

Base Information

• Chemical Name: 5-BroMo-1-isopropylbenzoiMidazole
• CAS No.: 1200114-01-7
• Molecular Formula: C10H11BrN2
• Molecular Weight: 239.11174
• Hs Code.: 2933290090
• Mol file: 1200114-01-7.mol

Synonyms:5-BroMo-1-isopropylbenzoiMidazole

Chemical Property of 5-BroMo-1-isopropylbenzoiMidazole

Chemical Property:

• PSA: 17.82000
• LogP: 3.37970

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-1-isopropylbenzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-1-isopropylbenzoiMidazole

There total 5 articles about 5-BroMo-1-isopropylbenzoiMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-N1-isopropylbenzene-1,2-diamine (1092292-39-1) + orthoformic acid triethyl ester (122-51-0) → 5-bromo-1-isopropyl-1H-benzo[d]imidazole (1200114-01-7)

Guidance literature:

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 100 ℃; for 8h;

Reference yield:

2-iodo-propane (75-30-9) + 5-bromo-1H-benzo[d]imidazole (4887-88-1) → 5-bromo-1-isopropyl-1H-benzo[d]imidazole (1200114-01-7) + 6-bromo-1-isopropyl-1H-benzo[d]imidazole

Guidance literature:

With caesium carbonate; In acetonitrile; at 82 ℃; Overall yield = 79 %; Overall yield = 2.41 g; Inert atmosphere;

DOI:10.1021/jacs.7b12779

Reference yield:

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) → 5-bromo-1-isopropyl-1H-benzo[d]imidazole (1200114-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 40 °C

2: tin(IV) chloride / ethanol / 4 h / Reflux

3: hydrogenchloride / water; N,N-dimethyl-formamide / 8 h / 100 °C

With hydrogenchloride; tin(IV) chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

4-Bromo-1-fluoro-2-nitrobenzene

4-bromo-2-nitro-N-(propan-2-yl)aniline

4-bromo-N¹-isopropylbenzene-1,2-diamine

orthoformic acid triethyl ester

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