Benzoic acid, 4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]-, lithiuM salt (1:1)

Base Information

• Chemical Name: Benzoic acid, 4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]-, lithiuM salt (1:1)
• CAS No.: 1445586-53-7
• Molecular Formula: C18H15LiN6O2
• Molecular Weight: 354.297
• Mol file: 1445586-53-7.mol

Synonyms:Benzoic acid, 4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]-, lithiuM salt (1:1)

Chemical Property of Benzoic acid, 4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]-, lithiuM salt (1:1)

Chemical Property:

• PSA: 143.73000
• LogP: 1.45970

Purity/Quality:

NLT 98% ^*data from raw suppliers

Lithium4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoate 99.12% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]-, lithiuM salt (1:1)

There total 3 articles about Benzoic acid, 4-[1-[(2,4-diaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]-, lithiuM salt (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid (146464-93-9) → lithium 10-propargyl-4-deoxy-4-amino-10-deazapteroate (1445586-53-7)

Guidance literature:

With lithium hydroxide; In water; at 0 - 20 ℃; for 1.75h;

Reference yield:

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid (146464-92-8) → lithium 10-propargyl-4-deoxy-4-amino-10-deazapteroate (1445586-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 120 °C

2: lithium hydroxide / water / 1.75 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate (146464-91-7) → lithium 10-propargyl-4-deoxy-4-amino-10-deazapteroate (1445586-53-7)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 1 h / Reflux

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 120 °C

3: lithium hydroxide / water / 1.75 h / 0 - 20 °C

With methanol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1-methyl-pyrrolidin-2-one; water;

upstream raw materials:

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate

4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid

Refernces