4-Chloro-6,8-dimethyl-2-phenylquinoline

Base Information

• Chemical Name: 4-Chloro-6,8-dimethyl-2-phenylquinoline
• CAS No.: 101602-31-7
• Molecular Formula: C₁₇H₁₄ClN
• Molecular Weight: 267.758
• Hs Code.: 2933499090
• European Community (EC) Number: 802-589-7
• DSSTox Substance ID: DTXSID40656303
• Wikidata: Q82570896
• Mol file: 101602-31-7.mol

Synonyms:4-Chloro-6,8-dimethyl-2-phenylquinoline;101602-31-7;DTXSID40656303;BEA60231;MFCD12674825;4-Chloro-6,8-dimethyl-2-phenylquinoline, AldrichCPR

Chemical Property of 4-Chloro-6,8-dimethyl-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 1.56E-06mmHg at 25°C
• Melting Point: 81 °C
• Boiling Point: 409.2°C at 760 mmHg
• PKA: 3.80±0.13(Predicted)
• Flash Point: 233.7°C
• PSA: 12.89000
• Density: 1.181g/cm³
• LogP: 5.17200
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 267.0814771
• Heavy Atom Count: 19
• Complexity: 300

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6,8-dimethyl-2-phenylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C2C(=C1)C(=CC(=N2)C3=CC=CC=C3)Cl)C

Technology Process of 4-Chloro-6,8-dimethyl-2-phenylquinoline

There total 3 articles about 4-Chloro-6,8-dimethyl-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,8-dimethyl-2-phenyl-quinolin-4-ol (93315-54-9) → 4-chloro-6,8-dimethyl-2-phenyl-quinoline (101602-31-7)

Guidance literature:

With trichlorophosphate;

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 4-chloro-6,8-dimethyl-2-phenyl-quinoline (101602-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated hydrochloric acid; water / und Behandeln des Reaktionsprodukts mit Schwefelsaeure und Acetanhydrid

2: phosphoryl chloride

With hydrogenchloride; water; trichlorophosphate;

Reference yield:

2,4-Xylidine (95-68-1) → 4-chloro-6,8-dimethyl-2-phenyl-quinoline (101602-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated hydrochloric acid; water / und Behandeln des Reaktionsprodukts mit Schwefelsaeure und Acetanhydrid

2: phosphoryl chloride

With hydrogenchloride; water; trichlorophosphate;

upstream raw materials:

6,8-dimethyl-2-phenyl-quinolin-4-ol

ethyl 3-oxo-3-phenylpropionate

2,4-Xylidine