2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine

Base Information

Chemical Name:2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine
CAS No.:743430-91-3
Molecular Formula:C₉H₁₀FNO₂
Molecular Weight:183.182
Hs Code.:2932999099
DSSTox Substance ID:DTXSID40462244
Nikkaji Number:J2.065.737E
Wikidata:Q82286746
Mol file:743430-91-3.mol

Synonyms:743430-91-3;2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine;2-(6-fluoro-1,3-benzodioxol-5-yl)ethanamine;2-(6-fluoro-benzo[1,3]dioxol-5-yl)-ethylamine;DTXSID40462244;AKOS006324364;6-Fluoro-1,3-benzodioxole-5-ethanamine

Suppliers and Price of 2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-AMINOETHYL-6-FLUORO-BENZO(1,3)DIOXOLE 95.00%
5MG
$ 501.04

Total 6 raw suppliers

Chemical Property of 2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine

Chemical Property:

Boiling Point:270.1±40.0 °C(Predicted)
PKA:9.36±0.10(Predicted)
PSA：44.48000
Density:1.296±0.06 g/cm3(Predicted)
LogP:1.75590
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:183.06955672
Heavy Atom Count:13
Complexity:179

Purity/Quality:

98% ^*data from raw suppliers

5-AMINOETHYL-6-FLUORO-BENZO(1,3)DIOXOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1OC2=C(O1)C=C(C(=C2)CCN)F

Technology Process of 2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine

There total 3 articles about 2-(6-Fluoro-2H-1,3-benzodioxol-5-yl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 743430-92-4
5-fluoro-6-(2-nitrovinyl)-benzo[1,3]dioxole

: 743430-91-3
2-(6-fluorobenzo[1,3]dioxol-5-yl)ethylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/j.tet.2004.05.033

Reference yield:

: 71144-36-0
2-fluoro-4,5-dihydroxy-benzaldehyde

: 743430-91-3
2-(6-fluorobenzo[1,3]dioxol-5-yl)ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / cesium carbonate / dimethylformamide / 3 h / 110 °C

2: 67 percent / AcONH₄ / 5 h / Heating

3: 51 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; ammonium acetate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.05.033

Reference yield:

: 479401-13-3
6-fluorobenzo[d][1,3]dioxole-5-carbaldehyde

: 743430-91-3
2-(6-fluorobenzo[1,3]dioxol-5-yl)ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / AcONH₄ / 5 h / Heating

2: 51 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran;
DOI:10.1016/j.tet.2004.05.033