(6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine

Base Information

• Chemical Name: (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine
• CAS No.: 743430-90-2
• Molecular Formula: C₁₈H₁₉BrFNO₄
• Molecular Weight: 412.256
• Mol file: 743430-90-2.mol

Synonyms:(6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine

Chemical Property of (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine

There total 5 articles about (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(6-Bromo-2,3-dimethoxy-phenyl)-meth-(E)-ylidene]-[2-(6-fluoro-benzo[1,3]dioxol-5-yl)-ethyl]-amine → (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine (743430-90-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2004.05.033

Reference yield:

2-fluoro-4,5-dihydroxy-benzaldehyde (71144-36-0) → (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine (743430-90-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 71 percent / cesium carbonate / dimethylformamide / 3 h / 110 °C

2: 67 percent / AcONH₄ / 5 h / Heating

3: 51 percent / LiAlH₄ / tetrahydrofuran

4: toluene / 3 h / Heating

5: 3.78 g / NaBH₄ / methanol / 1 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; ammonium acetate; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tet.2004.05.033

Reference yield:

6-fluorobenzo[d][1,3]dioxole-5-carbaldehyde (479401-13-3) → (6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]amine (743430-90-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / AcONH₄ / 5 h / Heating

2: 51 percent / LiAlH₄ / tetrahydrofuran

3: toluene / 3 h / Heating

4: 3.78 g / NaBH₄ / methanol / 1 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.tet.2004.05.033

upstream raw materials:

2-fluoro-4,5-dihydroxy-benzaldehyde

6-fluorobenzo[d][1,3]dioxole-5-carbaldehyde

5-fluoro-6-(2-nitrovinyl)-benzo[1,3]dioxole

2-(6-fluorobenzo[1,3]dioxol-5-yl)ethylamine

Downstream raw materials:

(6-bromo-2,3-dimethoxybenzyl)-[2-(6-fluorobenzo[1,3]dioxol-5-yl)ethyl]carbamic acid methyl ester