Technology Process of 1H-Pyrrolo[2,3-c]pyridine, 4-Methoxy-7-(5-Methyl-1H-1,2,4-triazol-1-yl)-
There total 1 articles about 1H-Pyrrolo[2,3-c]pyridine, 4-Methoxy-7-(5-Methyl-1H-1,2,4-triazol-1-yl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale
2.1: tert.-butylnitrite; sulfuric acid / 9.5 h / 20 - 43 °C / Large scale
3.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale
4.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale
5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 24 h / 25 - 35 °C / 1275.13 - 1500.15 Torr / Autoclave; Large scale
5.2: 10 - 30 °C / Large scale
6.1: trichlorophosphate / neat (no solvent) / 15 h / 40 - 102 °C / Large scale
7.1: methanol / toluene / 8 h / 45 - 55 °C / Large scale
8.1: Methyl isobutyl carbinol / 76 h / 130 - 145 °C / Large scale
With
methanol; Methyl isobutyl carbinol; copper(l) iodide; tert.-butylnitrite; propanoic acid methyl ester; sulfuric acid; 5%-palladium/activated carbon; hydrogen; nitric acid; trichlorophosphate;
In
tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
2.1: |Sandmeyer Reaction / 3.1: |Leimgruber-Batcho Indole Synthesis / 5.1: |Leimgruber-Batcho Indole Synthesis;
DOI:10.1021/acs.oprd.7b00134
