4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide

Base Information

Chemical Name:4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide
CAS No.:861453-16-9
Molecular Formula:C15H21N3O6
Molecular Weight:339.348
Hs Code.:
UNII:WJ3E2A4ATF
Mol file:861453-16-9.mol

Synonyms:4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide;861453-16-9;Gefitinib Impurity 22;4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzamide;WJ3E2A4ATF;SCHEMBL6532154;CS-0164136;2-nitrobenzamide? (Gefitinib Impurity pound(c);F19246;4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzamide;Benzamide, 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro-

Suppliers and Price of 4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 36 raw suppliers

Chemical Property of 4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide

Chemical Property:

PSA：119.84000
LogP:1.96480
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:339.14303540
Heavy Atom Count:24
Complexity:424

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)[N+](=O)[O-])C(=O)N)OCCCN2CCOCC2

Technology Process of 4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide

There total 4 articles about 4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 675126-26-8
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

: 861453-16-9
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

Guidance literature:: With potassium hydroxide; dihydrogen peroxide; In water; at 45 ℃; for 1h;

Reference yield:

: 621-59-0
isovanillin

: 861453-16-9
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium formate; formic acid; hydroxyammonium sulfate / 5 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C

3: nitric acid; sulfuric acid; acetic acid / 37 h / 0 - 20 °C

4: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C

With formic acid; hydroxyammonium sulfate; sulfuric acid; dihydrogen peroxide; nitric acid; sodium formate; potassium carbonate; acetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 52805-46-6
2-methoxy-5-cyanophenol

: 861453-16-9
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C

2: nitric acid; sulfuric acid; acetic acid / 37 h / 0 - 20 °C

3: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C

With sulfuric acid; dihydrogen peroxide; nitric acid; potassium carbonate; acetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;