2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

Base Information

• Chemical Name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
• CAS No.: 675126-26-8
• Molecular Formula: C15H19N3O5
• Molecular Weight: 321.333
• Hs Code.: 2934999090
• Mol file: 675126-26-8.mol

Synonyms:4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile;

Chemical Property of 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

Chemical Property:

• Melting Point: 127℃
• Boiling Point: 522.302 °C at 760 mmHg
• PKA: 6.96±0.10(Predicted)
• Flash Point: 269.679 °C
• PSA: 100.54000
• Density: 1.294 g/cm³
• LogP: 2.03728
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

There total 12 articles about 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile (675126-28-0) → 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile (675126-26-8)

Guidance literature:

With sulfuric acid; nitric acid; acetic acid; at 20 ℃; for 50h;

DOI:10.1016/j.bmcl.2006.04.080

Reference yield: 94.0%

4-(3-chloropropyl)morpholine (7357-67-7) + 2-nitro-4-methoxy-5-hydroxybenzonitrile → 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile (675126-26-8)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 85 ℃; for 4h;

Reference yield: 56.15%

morpholine (110-91-8,99108-56-2) + C11H11ClN2O4 (1315512-61-8) → 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile (675126-26-8)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 9h;

upstream raw materials:

4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile

4-(3-chloropropyl)morpholine

isovanillin

4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldoxime

Downstream raw materials:

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline

2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

Refernces

• 1、 Li, Wen,Chen, Shu-Yi,Hu, Wei-Nan,Zhu, Mei,Liu, Jia-Min,Fu, Yi-Hong,Wang, Zhen-Chao,OuYang, Gui-Ping. "Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents". . p. 536 - 542. Retrieved 2020/03/27.
• 2、 -. "Preparing method of gefitinib intermediate". Paragraph 0027; 0028; 0029. . Retrieved 2019/05/04.