ETHYL 4-NITROPHENYLGLYOXYLATE

Base Information

• Chemical Name: ETHYL 4-NITROPHENYLGLYOXYLATE
• CAS No.: 70091-75-7
• Molecular Formula: C10H9NO5
• Molecular Weight: 225.201
• Hs Code.: 2918300090
• Mol file: 70091-75-7.mol

Synonyms:Ethyl (4-nitrophenyl)(oxo)acetate;ETHYL 4-NITROPHENYLGLYOXYLATE;Ethyl 4-nitrobenzoylformate~4-Nitrophenylglyoxylic acid ethyl ester;4-nitrophenylglyoxylic acid ethyl ester;ethyl 4-nitrobenzoylformate;Ethyl 4-nitrophenylglyoxylate, 98+%;Ethyl p-nitrophenylglyoxylate

Chemical Property of ETHYL 4-NITROPHENYLGLYOXYLATE

Chemical Property:

• Vapor Pressure: 1.71E-05mmHg at 25°C
• Melting Point: 40-42°C
• Boiling Point: 152-157°C 0,5mm
• Flash Point: 152-157°C/0.5mm
• PSA: 89.19000
• Density: 1.318g/cm³
• LogP: 1.86380

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-nitrophenylglyoxylate AldrichCPR ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-NITROPHENYLGLYOXYLATE

There total 15 articles about ETHYL 4-NITROPHENYLGLYOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl α-diazo-4-nitrophenylacetate (3900-83-2) → ethyl 2-(4-nitrophenyl)-2-oxoacetate (70091-75-7)

Guidance literature:

With copper(II) sulfate; In water; at 60 ℃; for 12h;

Reference yield: 86.0%

ethanol (64-17-5) + 2-nitro-1-(4-nitrophenyl)-1-ethanone (46417-99-6) → ethyl 2-(4-nitrophenyl)-2-oxoacetate (70091-75-7)

Guidance literature:

With 1-[4-(diacetoxyiodo)benzyl]-3-methylimidazolium tetrafluoroborate; for 1h; Reflux;

DOI:10.1055/s-0035-1562535

Reference yield: 65.0%

ethanol (64-17-5) + (4-Nitrophenyl)acetylene (937-31-5) → ethyl 2-(4-nitrophenyl)-2-oxoacetate (70091-75-7)

Guidance literature:

With iodosylbenzene; silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 40 ℃; for 3h;

DOI:10.1021/acs.orglett.5b03484

upstream raw materials:

ethanol

2-hydroxy-2-(4-nitrophenyl)acetic acid

2-Ethoxy-1-(4-nitro-phenyl)-propenone

ethyl 2-chloro-2-(4-nitrophenyl)ethanoate

Downstream raw materials:

(R,R)-ethyl 2-hydroxy-2-(4-nitrophenyl)-2-(5-oxo-2,5-dihydrofuran-2-yl)acetate

Refernces

• 1、 Chen, Liang,Gao, Meng,Lu, Cuifen,Ma, Chao,Ruan, Mengyao,Wen, Ziyang,Yang, Fan,Yang, Guichun. "Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters". . p. 2168 - 2171. Retrieved 2022/02/17.
• 2、 Ni, Ke,Meng, Ling-Guo,Ruan, Hongjie,Wang, Lei. "Controllable chemoselectivity in the coupling of bromoalkynes with alcohols under visible-light irradiation without additives: Synthesis of propargyl alcohols and α-ketoesters". supporting information. p. 8438 - 8441. Retrieved 2019/07/22.