SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea

Base Information

• Chemical Name: SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea
• CAS No.: 1629138-41-5
• Molecular Formula: C20H31N3O
• Molecular Weight: 0
• Mol file: 1629138-41-5.mol

Synonyms:1629138-41-5;SRI011381;SRI-011381

Chemical Property of SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea

Chemical Property:

• PSA: 44.37000
• LogP: 4.25020

Purity/Quality:

99%+, ^*data from raw suppliers

SRI-011381 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: SRI-011381 is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer''s disease.

Technology Process of SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea

There total 3 articles about SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-((1-benzyl-3-cyclohexylureido)methyl)piperidine-1-carboxylate → 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea (1629138-41-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 4h;

Reference yield:

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (144222-22-0) → 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea (1629138-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 8 h / 20 °C

1.2: 20 °C

2.1: dichloromethane / 20 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane; water / 4 h / 20 °C

With trifluoroacetic acid; In methanol; dichloromethane; water;

Reference yield:

benzaldehyde (100-52-7) → 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea (1629138-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 8 h / 20 °C

1.2: 20 °C

2.1: dichloromethane / 20 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane; water / 4 h / 20 °C

With trifluoroacetic acid; In methanol; dichloromethane; water;

upstream raw materials:

benzaldehyde

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

Refernces