4-(3,4-Difluorophenyl)-4-piperidinol

Base Information

Chemical Name:4-(3,4-Difluorophenyl)-4-piperidinol
CAS No.:233261-74-0
Molecular Formula:C11H13F2NO
Molecular Weight:213.227
Hs Code.:
DSSTox Substance ID:DTXSID20595509
Wikidata:Q82490523
Mol file:233261-74-0.mol

Synonyms:4-(3,4-DIFLUOROPHENYL)-4-PIPERIDINOL;233261-74-0;4-(3,4-difluorophenyl)piperidin-4-ol;SCHEMBL533971;DTXSID20595509;AKOS012098107;CS-0353308;C78078;EN300-140817

Suppliers and Price of 4-(3,4-Difluorophenyl)-4-piperidinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
4-(3,4-Difluorophenyl)-4-piperidinolHCl 97%
1g
$ 238.33

Total 5 raw suppliers

Chemical Property of 4-(3,4-Difluorophenyl)-4-piperidinol

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:213.09652036
Heavy Atom Count:15
Complexity:219

Purity/Quality:

99% ^*data from raw suppliers

4-(3,4-Difluorophenyl)-4-piperidinolHCl 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1(C2=CC(=C(C=C2)F)F)O

Technology Process of 4-(3,4-Difluorophenyl)-4-piperidinol

There total 6 articles about 4-(3,4-Difluorophenyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 871112-36-6
tert-butyl 4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate

: 233261-74-0
4-(3,4-difluorophenyl)-4-hydroxypiperidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 80.0%

: 874352-24-6
N-benzyl-4-hydroxy-4-(3,4-difluorophenyl)piperidine

: 233261-74-0
4-(3,4-difluorophenyl)-4-hydroxypiperidine

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol;

Reference yield:

: 90897-92-0
3,4-difluorophenylmagnesium bromide

: 233261-74-0
4-(3,4-difluorophenyl)-4-hydroxypiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 18 h / -78 - 20 °C / Inert atmosphere

1.2: -78 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;