(2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide

Base Information

Chemical Name:(2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide
CAS No.:160707-37-9
Molecular Formula:C13H18N2O
Molecular Weight:218.299
Hs Code.:
UNII:BRX3Q9GT5F,HS1P4T2LCV
DSSTox Substance ID:DTXSID501284531
ChEMBL ID:CHEMBL1253490
Mol file:160707-37-9.mol

Synonyms:160707-37-9;50288-62-5;(2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide;(+/-)-threo-Methylphenidate amide;BRX3Q9GT5F;HS1P4T2LCV;D-threo-alpha-Phenyl-2-piperidineacetamide;CHEMBL1253490;(D,L)-threo-alpha-Phenyl-2-piperidineacetamide;(alphaR,2R)-alpha-Phenyl-2-piperidineacetamide;alpha-Phenyl-2-piperidineacetamide, threo-(+)-;alpha-Phenyl-2-piperidineacetamide, threo-(+/-)-;UNII-BRX3Q9GT5F;UNII-HS1P4T2LCV;Methylphenidate impurity C;D03NUN;SCHEMBL14453323;DTXSID501284531;BDBM50327105;D-threo-?-Phenyl-2-piperidineacetamide;Threo-alpha-phenyl-2-piperidineacetamide, (+/-)-;(2RS)-2-Phenyl-2-[(2RS)-piperidin-2-yl]acetamide;2-Piperidineacetamide, alpha-phenyl-, (alphaR,2R)-;(D,L)-THREO-.ALPHA.-PHENYL-2-PIPERIDINEACETAMIDE;(.ALPHA.R,2R)-.ALPHA.-PHENYL-2-PIPERIDINEACETAMIDE;.ALPHA.-PHENYL-2-PIPERIDINEACETAMIDE, THREO-(+)-;2-Piperidineacetamide, alpha-phenyl-, (R*,R*)-, (+/-)-;.ALPHA.-PHENYL-2-PIPERIDINEACETAMIDE, THREO-(+/-)-;METHYLPHENIDATE HYDROCHLORIDE IMPURITY D [EP IMPURITY];THREO-.ALPHA.-PHENYL-2-PIPERIDINEACETAMIDE, (+/-)-;2-PIPERIDINEACETAMIDE, .ALPHA.-PHENYL-, (.ALPHA.R,2R)-;2-PIPERIDINEACETAMIDE, .ALPHA.-PHENYL-, (R*,R*)-, (+/-)-;2-Piperidineacetamide, alpha-phenyl-, (alphaR,2R)-rel-;2-Piperidineacetamide, alpha-phenyl-, (R*,R*)-;(2RS)-2-phenyl-2-[(2RS)-piperidin-2-yl]ethanamide;(2RS)-2-phenyl-2-[(2RS)-piperidin-2-yl]acetamide;Methylphenidate Hydrochloride Imp. C (EP)

Suppliers and Price of (2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
D-threo-α-Phenyl-2-piperidineacetamide
50mg
$ 1320.00

Total 2 raw suppliers

Chemical Property of (2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide

Chemical Property:

PSA：55.12000
LogP:2.42670
Storage Temp.:Refrigerator
Solubility.:Chloroform, Methanol
XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:218.141913202
Heavy Atom Count:16
Complexity:236

Purity/Quality:

96% ^*data from raw suppliers

D-threo-α-Phenyl-2-piperidineacetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCNC(C1)C(C2=CC=CC=C2)C(=O)N
Isomeric SMILES:C1CCN[C@H](C1)[C@@H](C2=CC=CC=C2)C(=O)N
Uses Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)

Technology Process of (2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide

There total 10 articles about (2R)-2-Phenyl-2-[(2R)-piperidin-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: dl-threo-α-phenyl-α-(2-piperidyl)acetamide

: 160707-37-9
d-threo-2-phenyl-2-(piperidine-2-yl)acetamide

Guidance literature:: dl-threo-α-phenyl-α-(2-piperidyl)acetamide; With L-Tartaric acid; In ethanol; water; at 20 ℃; for 18h; Resolution of racemate;

In water; pH=13; Product distribution / selectivity;

Reference yield: 88.0%

: 160707-36-8
l-erythro-α-phenyl-α-piperidyl-(2)-acetamide

: 160707-37-9
d-threo-2-phenyl-2-(piperidine-2-yl)acetamide

Guidance literature:: l-erythro-α-phenyl-α-piperidyl-(2)-acetamide; With potassium tert-butylate; In toluene; at 20 - 70 ℃; for 5 - 16h;

With hydrogenchloride; In water; toluene; Product distribution / selectivity;