6-Bromo-8-fluoroquinoline

Base Information

• Chemical Name: 6-Bromo-8-fluoroquinoline
• CAS No.: 220513-46-2
• Molecular Formula: C9H5BrFN
• Molecular Weight: 226.048
• Hs Code.: 2933499090
• Mol file: 220513-46-2.mol

Synonyms:6-Bromo-8-fluoroquinoline;6-Bromo-8-fluoro-1-azanaphthalene;6-Bromo-8-fluoroquinoline 95%;6-Bromo-8-fluoroquinoline95%

Chemical Property of 6-Bromo-8-fluoroquinoline

Chemical Property:

• Melting Point: 104-106°C
• Boiling Point: 294.9±20.0 °C(Predicted)
• PKA: 1.14±0.20(Predicted)
• PSA: 12.89000
• Density: 1.647±0.06 g/cm3(Predicted)
• LogP: 3.13640
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-8-fluoroquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

Useful:

Technology Process of 6-Bromo-8-fluoroquinoline

There total 3 articles about 6-Bromo-8-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-bromo-2-fluoroaniline (367-24-8) + sodium 3-nitrobenzenesulfonate (127-68-4) → 6-bromo-8-fluoro-quinoline (220513-46-2)

Guidance literature:

4-bromo-2-fluoroaniline; sodium 3-nitrobenzenesulfonate; With sulfuric acid; glycerol; In water; at 85 - 133 ℃;

With ammonia; water; pH=7;

Reference yield: 96.9%

4-bromo-2-fluoroaniline (367-24-8) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 6-bromo-8-fluoro-quinoline (220513-46-2)

Guidance literature:

glycerol; With sulfuric acid; sodium 3-nitrobenzenesulfonate; In water; at 110 ℃;

4-bromo-2-fluoroaniline; In water; at 95 - 140 ℃;

With ammonia; In water; pH=7;

Reference yield: 22.0%

4-bromo-2-fluoroaniline (367-24-8) + acrolein (107-02-8,25068-14-8) → 6-bromo-8-fluoro-quinoline (220513-46-2)

Guidance literature:

4-bromo-2-fluoroaniline; acrolein; With hydrogenchloride; In water; toluene; at 100 ℃;

With sodium hydroxide; In water;

upstream raw materials:

4-bromo-2-fluoroaniline

glycerol

sodium 3-nitrobenzenesulfonate

acrolein

Downstream raw materials:

(8-fluoroquinolin-6-yl)boronic acid

8-fluoroquinoline-6-carboxylic acid

8-fluoro-6-(phenylmethyl)quinoline