3,5-Dichloro-6-ethylpyrazinecarboxamide

Base Information

• Chemical Name: 3,5-Dichloro-6-ethylpyrazinecarboxamide
• CAS No.: 313340-08-8
• Molecular Formula: C7H7Cl2N3O
• Molecular Weight: 220.058
• Hs Code.: 2933990090
• Mol file: 313340-08-8.mol

Synonyms:3,5-Dichloro-6-ethylpyrazinecarboxamide;3,5-Dichloro-6-ethylpyrazine-2-carboxaMide;3,5-Dichloro-6-ethyl-pyrazine-2-carboxylic acid amide;3,5-dichloro-6-ethyl-2-Pyrazinecarboxamide;2-Pyrazinecarboxamide, 3,5-dichloro-6-ethyl-

Chemical Property of 3,5-Dichloro-6-ethylpyrazinecarboxamide

Chemical Property:

• Boiling Point: 271.3±40.0 °C(Predicted)
• PKA: 13.10±0.50(Predicted)
• PSA: 68.87000
• Density: 1.454±0.06 g/cm3(Predicted)
• LogP: 2.14500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dichloro-6-ethyl-2-pyrazinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dichloro-6-ethyl-2-pyrazinecarboxamide acts as a reagent in the preparation of nitrogen-containing heterocyclic derivatives as remedies for complications of diabetes.

Technology Process of 3,5-Dichloro-6-ethylpyrazinecarboxamide

There total 5 articles about 3,5-Dichloro-6-ethylpyrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

3,5-dichloro-2-ethylpyrazine (1314936-02-1) + formamide (77287-34-4,77287-35-5,60100-09-6) → 3,5-dichloro-6-ethylpyrazine-2-carboxamide (313340-08-8)

Guidance literature:

With sodium persulfate; at 80 - 90 ℃; for 4h; Temperature;

Reference yield: 85.0%

3,5-dichloro-6-ethylpyrazine-2-carbonitrile (1254055-46-3) → 3,5-dichloro-6-ethylpyrazine-2-carboxamide (313340-08-8)

Guidance literature:

With acetic acid; acetic acid hydrobromide; at 20 ℃; Reagent/catalyst;

Reference yield:

C7H8N4O → 3,5-dichloro-6-ethylpyrazine-2-carboxamide (313340-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) chloride; isopentyl nitrite / acetonitrile / 12 h / 0 - 20 °C

2: thionyl chloride / toluene / 90 °C

3: acetic acid; acetic acid hydrobromide / 20 °C

With thionyl chloride; acetic acid; acetic acid hydrobromide; copper(l) chloride; isopentyl nitrite; In toluene; acetonitrile;

upstream raw materials:

3,5-dichloro-6-ethylpyrazine-2-carbonitrile

3,5-dichloro-2-ethylpyrazine

formamide

3,5-dichloropyrazine-2-carboxamide

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