(S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride

Base Information

Chemical Name:(S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride
CAS No.:148719-90-8
Molecular Formula:C17H20ClNO
Molecular Weight:289.805
Hs Code.:2933990090
UNII:446PL4A4AG
DSSTox Substance ID:DTXSID201345192
Mol file:148719-90-8.mol

Synonyms:148719-90-8;(S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride;diphenyl-[(2S)-pyrrolidin-2-yl]methanol;hydrochloride;446PL4A4AG;(S)-2-(Hydroxydiphenylmethyl)pyrrolidine hydrochloride;diphenyl[(2S)-pyrrolidin-2-yl]methanol hydrochloride;UNII-446PL4A4AG;SCHEMBL9277459;DTXSID201345192;(S)-|A,|A-Diphenylprolinol Hydrochloride;(2S)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol hydrochloride;2-Pyrrolidinemethanol, alpha,alpha-diphenyl-, hydrochloride, (2S)-;2-Pyrrolidinemethanol, alpha,alpha-diphenyl-, hydrochloride, (S)-;(2S)-.ALPHA.,.ALPHA.-DIPHENYL-2-PYRROLIDINEMETHANOL HYDROCHLORIDE;(2S)-alphalpha,alphalpha-Diphenyl-2-pyrrolidinemethanol hydrochloride;2-Pyrrolidinemethanol, alpha,alpha-diphenyl-, hydrochloride (1:1), (2S)-;2-PYRROLIDINEMETHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, HYDROCHLORIDE (1:1), (2S)-;2-PYRROLIDINEMETHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, HYDROCHLORIDE, (2S)-;2-PYRROLIDINEMETHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, HYDROCHLORIDE, (S)-

Suppliers and Price of (S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-α,α-DiphenylprolinolHydrochloride
25mg
$ 155.00

Total 3 raw suppliers

Chemical Property of (S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride

Chemical Property:

PSA：32.26000
LogP:3.80530
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:289.1233420
Heavy Atom Count:20
Complexity:261

Purity/Quality:

≥95% ^*data from raw suppliers

(S)-α,α-DiphenylprolinolHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl
Isomeric SMILES:C1C[C@H](NC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl
Uses (S)-α,α-Diphenylprolinol is the (S)-enantiomer of Diphenylprolinol, a relatively mild norepinephrine-dopamine reuptake inhibitor. (S)-α,α-Diphenylprolinol is less pharmacologically active than its (R)-enatiomer.

Technology Process of (S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride

There total 4 articles about (S)-Diphenyl(pyrrolidin-2-yl)methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 148719-90-8
(S)-α,α-diphenyl-2-pyrrolidinemethanol hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 0 - 20 ℃;

Reference yield: 91.0%

: 137496-68-5
2-[hydroxy(diphenyl)methyl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 148719-90-8
(S)-α,α-diphenyl-2-pyrrolidinemethanol hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1055/s-2003-44365

Reference yield:

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 148719-90-8
(S)-α,α-diphenyl-2-pyrrolidinemethanol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / tetrahydrofuran / 20 °C

2: 91 percent / HCl / ethyl acetate

With hydrogenchloride; In tetrahydrofuran; ethyl acetate; 1: Grignard reaction;
DOI:10.1055/s-2003-44365