2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL

Base Information

• Chemical Name: 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL
• CAS No.: 2814-20-2
• Molecular Formula: C8H12 N2 O
• Molecular Weight: 152.196
• Hs Code.: 29335990
• Mol file: 2814-20-2.mol

Synonyms:4(1H)-Pyrimidinone,2-isopropyl-6-methyl- (8CI); 4(1H)-Pyrimidinone, 6-methyl-2-(1-methylethyl)-(9CI); 4-Pyrimidinol, 2-isopropyl-6-methyl- (6CI,7CI);2-Isopropyl-4-methyl-6-hydroxypyrimidine; 2-Isopropyl-4-methyl-6-pyrimidinone;2-Isopropyl-4-methylpyrimidin-6-ol; 2-Isopropyl-6-methyl-4(3H)-pyrimidone;2-Isopropyl-6-methyl-4-hydroxypyrimidine; 2-Isopropyl-6-methyl-4-pyrimidinol;2-Isopropyl-6-methyl-4-pyrimidone; 4-Hydroxy-2-isopropyl-6-methylpyrimidine; G27550; IMHP; Pyrimidinol

Chemical Property of 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL

Chemical Property:

• Appearance/Colour: BEIGE NEEDLES
• Vapor Pressure: 0.0655mmHg at 25°C
• Melting Point: 172-175 °C(lit.)
• Refractive Index: 1.4940 (estimate)
• Boiling Point: 230.5°Cat760mmHg
• PKA: 9.74±0.50(Predicted)
• Flash Point: 93.2°C
• PSA: 46.01000
• Density: 1.11g/cm³
• LogP: 1.61400
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Isopropyl-6-methyl-4-pyrimidone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides.

Technology Process of 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL

There total 15 articles about 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-Ethyl-2-isopropyl-6-methyl-3H-pyrimidin-4-one (87268-60-8) → 2-Isopropyl-6-methyl-4(3H)-pyrimidone (2814-20-2)

Guidance literature:

With sodium amide; In ammonia;

Reference yield: 95.0%

N-Methyl-2-isopropyl-4-methyl-pyrimidine-6-one (87268-59-5) → 2-Isopropyl-6-methyl-4(3H)-pyrimidone (2814-20-2)

Guidance literature:

With sodium amide; In ammonia;

Reference yield: 79.0%

2-Isopropylidene-6-methyl-2,3-dihydro-[1,3]thiazin-4-one (77831-94-8) → 2-Isopropyl-6-methyl-4(3H)-pyrimidone (2814-20-2)

Guidance literature:

With ammonia; In ethanol; water; for 0.666667h; Heating;

upstream raw materials:

2-(β,β'-dipiperidino-isopropyl)-6-methyl-3H-pyrimidin-4-one

2-methylpropanimidamide hydrochloride

ethyl acetoacetate

isobutyramidine

Downstream raw materials:

8-benzyl-2-isopropyl-4-methyl-5,8-dihydropyrido[2,3-d]pyrimidine

N-benzyl-N-cyclopropyl-5-iodo-2-isopropyl-6-methylpyrimidin-4-amine

2-(2-isopropyl-4-methyl-6-phenylpyrido[2,3-d]pyrimidin-8(5H)-yl)-N-(4-methoxybenzyl)acetamide

N-(4-chlorobenzyl)-2-(2-isopropyl-4-methylpyrido[2,3-d]pyrimidin-8(5H)-yl)acetamide

Refernces

• 1、 Ebrahimi, Arash,Mohammadsalehi, Maedeh,Nassireslami, Ehsan,Zibaseresht, Ramin. "Ultra-fast catalytic detoxification of organophosphates by nano-zeolitic imidazolate frameworks". . . Retrieved 2020/04/29.
• 2、 Lu, Zhong-Lin,Neverov, Alexei A.,Brown, R. Stan. "An ortho-palladated dimethylbenzylamine complex as a highly efficient turnover catalyst for the decomposition of P=S insecticides. Mechanistic studies of the methanolysis of some P=S-containing phosphorothioate triesters". . p. 3379 - 3387. Retrieved 2007/10/03.