BLU-554

Base Information

Chemical Name:BLU-554
CAS No.:1707289-21-1
Molecular Formula:C24H24Cl2N4O4
Molecular Weight:503.38
Hs Code.:
Mol file:1707289-21-1.mol

Synonyms:BLU-554;N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

Suppliers and Price of BLU-554

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide
1mg
$ 65.00

DC Chemicals
BLU554(Fisogatinib) >98%
100 mg
$ 700.00

DC Chemicals
BLU554(Fisogatinib) >98%
250 mg
$ 1200.00

Crysdot
BLU-554 97%
10mg
$ 180.00

Crysdot
BLU-554 97%
50mg
$ 500.00

Crysdot
BLU-554 97%
25mg
$ 350.00

ChemScene
Fisogatinib 99.16%
100mg
$ 1300.00

ChemScene
Fisogatinib 99.16%
50mg
$ 750.00

ChemScene
Fisogatinib 99.16%
10mg
$ 250.00

ChemScene
Fisogatinib 99.16%
5mg
$ 150.00

Total 23 raw suppliers

Chemical Property of BLU-554

Chemical Property:

PKA:13.77±0.40(Predicted)
PSA：94.60000
Density:1.39±0.1 g/cm3(Predicted)
LogP:4.95630

Purity/Quality:

99%, ^*data from raw suppliers

N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-[(3S,4S)-3-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-2-propenamide is a fibroblast growth factor receptor 4 (FGFR4) inhibitor. BLU-554

Technology Process of BLU-554

There total 9 articles about BLU-554 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: (3S,4S)-N₃-(6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)tetrahydro-2H-pyran-3,4-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1707289-21-1
N?((3S,4S)?3?((6?(2,6?dichloro?3,5?dimethoxyphenyl)quinazoline?2?yl)amino)tetrahydro?2H-pyran-4-yl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: N-((3S,4S)-4-azidotetrahydro-2H-pyran-3-yl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-amine

: 1707289-21-1
N?((3S,4S)?3?((6?(2,6?dichloro?3,5?dimethoxyphenyl)quinazoline?2?yl)amino)tetrahydro?2H-pyran-4-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate; methanol / 1 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: (3S,4S)-4-azidotetrahydro-2H-pyran-3-amine

: 1707289-21-1
N?((3S,4S)?3?((6?(2,6?dichloro?3,5?dimethoxyphenyl)quinazoline?2?yl)amino)tetrahydro?2H-pyran-4-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium carbonate / water; 1-methyl-pyrrolidin-2-one / 100 °C

2: palladium on activated charcoal; hydrogen / ethyl acetate; methanol / 1 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; ethyl acetate;