2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline

Base Information

• Chemical Name: 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline
• CAS No.: 1538605-06-9
• Molecular Formula: C₁₆H₁₁Cl₃N₂O₂
• Molecular Weight: 369.635
• Mol file: 1538605-06-9.mol

Synonyms:2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline

Chemical Property of 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline

There total 7 articles about 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-chloro-6-(3,5-dimethoxyphenyl)quinazoline (1538605-05-8) → 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline (1538605-06-9)

Guidance literature:

With sulfuryl dichloride; In tetrahydrofuran; at -20 ℃; for 1h;

Reference yield:

6-bromo-2-chloroquinazoline (882672-05-1) → 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline (1538605-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Cs₂CO₃; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / tetrahydrofuran; water monomer; 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Microwave irradiation

2: sulfuryl dichloride / tetrahydrofuran / 1 h / -20 °C

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sulfuryl dichloride; Cs₂CO₃; In tetrahydrofuran; 1,4-dioxane; water monomer;

Reference yield:

3,5-dimethoxyphenylboronic acid (192182-54-0) → 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline (1538605-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Cs₂CO₃; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / tetrahydrofuran; water monomer / 4 h / Reflux; Inert atmosphere

2: sulfuryl dichloride / tetrahydrofuran; acetonitrile / 2.17 h / -20 - 30 °C / Inert atmosphere

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sulfuryl dichloride; Cs₂CO₃; In tetrahydrofuran; water monomer; acetonitrile;

upstream raw materials:

5-Bromo-2-aminobenzoic acid

(2-amino-5-bromophenyl)methanol

2-amino-5-bromobenzaldehyde

6-bromoquinazolin-2-ol

Downstream raw materials:

6-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(2-methyl-6-nitrophenyl)quinazolin-2-amine

BLU9931

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