Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 454170-16-2
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.266
• Mol file: 454170-16-2.mol

Synonyms:Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI);(1R,2R)-trans-N-Boc-2-Aminocyclopentanol;tert-butyl (1R,2R)-2-hydroxycyclopentylcarbaMate;(1R,2R)-2-((tert-Butoxycarbonyl)amino)-1-cyclopentanol;[(1R,2R)-2-Hydroxycyclopentyl]carbamic acid 1,1-dimethylethyl ester;(1R,2R)-trans-N-Boc-2-aminocyclopentanol >=98.5% (GC);1-N-Boc-(1R,2R)-1- aminocyclopentan-2-ol

Chemical Property of Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Melting Point: 87.0℃
• Boiling Point: 320.8±31.0 °C(Predicted)
• PKA: 12.09±0.40(Predicted)
• PSA: 58.56000
• Density: 1.08±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 1.81540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(1R,2R)-trans-N-Boc-2-aminocyclopentanol ≥98.5% (GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 9764083
• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

There total 9 articles about Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1R, 2R)-2-benzyloxycyclopentyl-(tert-butoxycarbonyl)amine (1186017-97-9) → (1R,2R)-trans-2-(tertbutoxycarbonylamino)cyclopentanol (454170-16-2,1330069-67-4,155837-14-2)

Guidance literature:

With palladium hydroxide, 20 wt% on carbon; cyclohexene; In ethanol; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01402

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R,2R)-2-aminocyclopentan-1-ol hydrochloride (68327-11-7) → (1R,2R)-trans-2-(tertbutoxycarbonylamino)cyclopentanol (454170-16-2,1330069-67-4,155837-14-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 83.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R,2R)-trans-2-azidocyclopentanol (110716-79-5,88807-02-7) → (1R,2R)-trans-2-(tertbutoxycarbonylamino)cyclopentanol (454170-16-2,1330069-67-4,155837-14-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; at 20 ℃; for 3.5h; under 1810.02 - 2068.59 Torr;

DOI:10.1021/jo049442+

upstream raw materials:

di-tert-butyl dicarbonate

(1R,2R)-2-aminocyclopentanol

(1R,2R)-trans-2-azidocyclopentanol

(±)-trans-2-azidocyclopentanol

Downstream raw materials:

(1S,2R)-2-(N-t-butyloxycarbonylamino)-1-aminocyclopentane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 454170-16-2 Carbamic acid, [(1R,2R)-2-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send