C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE
• CAS No.: 407640-03-3
• Molecular Formula: C12H18Cl4N2O
• Molecular Weight: 348.09612
• Mol file: 407640-03-3.mol

Synonyms:C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

Chemical Property of C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 38.49000
• LogP: 4.39510

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

There total 12 articles about C-[4-(3,4-DICHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione (407640-38-4) → [4-(3,4-dichlorobenzyl)morpholin-2-yl]methylamine (407640-03-3)

Guidance literature:

With dimethyl amine;

DOI:10.1016/j.tetlet.2005.05.038

Reference yield:

N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-2,2,2-trifluoroacetamide → [4-(3,4-dichlorobenzyl)morpholin-2-yl]methylamine (407640-03-3)

Guidance literature:

With potassium carbonate; In methanol; water; at 22 ℃; for 18h;

Reference yield:

2-oxiranylmethylisoindole-1,3-dione (5455-98-1) + N-(3,4-dichlorobenzyl)ethanoloamine (40172-06-3) → [4-(3,4-dichlorobenzyl)morpholin-2-yl]methylamine (407640-03-3)

Guidance literature:

2-oxiranylmethylisoindole-1,3-dione; N-(3,4-dichlorobenzyl)ethanoloamine; at 80 ℃; for 3h;

With sulfuric acid; at 150 ℃; for 24h;

With sodium hydroxide; In water; pH=~ 12; Product distribution / selectivity;

upstream raw materials:

N-[4-(3,4-Dichloro-benzyl)-morpholin-2-ylmethyl]-acetamide

2-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione

4-(3,4-dichloro-benzyl)-2-vinyl-morpholine

N-(3,4-dichlorobenzyl)ethanoloamine

Downstream raw materials:

N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-(4-fluorophenyl)acetamide

2-(4-Chlorophenyl)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide

N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-phenoxyacetamide

2-(2-Chlorophenyl)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide