2-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione
CAS No.:407640-38-4
Molecular Formula:C₂₀H₁₈Cl₂N₂O₃
Molecular Weight:405.281
Hs Code.:

Synonyms:2-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione

Suppliers and Price of 2-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

Chemical Property:

Vapor Pressure:0mmHg at 25°C

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

There total 8 articles about 2-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 914980-56-6
N-(3,4-dichlorobenzyl)-2(R)-(chloromethyl)morpholine

: 1074-82-4
potassium phtalimide

: 407640-38-4
2-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: DOI:10.1055/s-2006-948184

Reference yield:

: 40172-06-3
N-(3,4-dichlorobenzyl)ethanoloamine

: 161596-47-0
(S)-N-glycidylphthalimide

: 407640-38-4
2-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: N-(3,4-dichlorobenzyl)ethanoloamine; (S)-N-glycidylphthalimide; In tetrahydrofuran; for 21.5h; Heating / reflux;

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 3 - 22 ℃; for 30.25h;

Reference yield:

: 40172-06-3
N-(3,4-dichlorobenzyl)ethanoloamine

: 407640-38-4
2-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 18 h / 20 °C

2: 73 percent / PPh₃; DIAD; acetyl chloride / toluene; propan-2-ol / 0.25 h

With di-isopropyl azodicarboxylate; acetyl chloride; triphenylphosphine; In isopropyl alcohol; toluene; 2: Mitsunobu cyclisation;
DOI:10.1055/s-2006-948184