3-O-Methyl 6-Hydroxy 17β-Estradiol

Base Information

Chemical Name:3-O-Methyl 6-Hydroxy 17β-Estradiol
CAS No.:109835-83-8
Molecular Formula:C₁₉H₂₆O₃
Molecular Weight:302.414
Hs Code.:
Mol file:109835-83-8.mol

Synonyms:(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-6,17-diol;

Suppliers and Price of 3-O-Methyl 6-Hydroxy 17β-Estradiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-O-Methyl6-Hydroxy17β-Estradiol
2mg
$ 60.00

Medical Isotopes, Inc.
3-O-Methyl6-Hydroxy17β-Estradiol
50 mg
$ 2000.00

Medical Isotopes, Inc.
3-O-Methyl6-Hydroxy17β-Estradiol
5 mg
$ 625.00

Total 1 raw suppliers

Chemical Property of 3-O-Methyl 6-Hydroxy 17β-Estradiol

Chemical Property:

PSA：49.69000
LogP:3.40310
Solubility.:Dichloromethane

Purity/Quality:: 3-O-Methyl6-Hydroxy17β-Estradiol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses An Estradiol derivative.

Technology Process of 3-O-Methyl 6-Hydroxy 17β-Estradiol

There total 2 articles about 3-O-Methyl 6-Hydroxy 17β-Estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19115-79-8
3-O-methylestra-1,3,5⁽¹⁰⁾-trien-3-ol-6,17-dione

: 109835-83-8
(8R,9S,13S,14S,17S)-3-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-6,17-diol

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; In ethanol; for 20h;

Reference yield:

: 4551-97-7,7291-47-6,109835-83-8
6-Hydroxy-oestradiol-17β-3-methylaether

Guidance literature:: 6-Hydroxy-oestradiol-17β, Dimethylsulfat;
DOI:10.1016/0006-3002(60)90192-X

Reference yield:

: 109835-83-8
(8R,9S,13S,14S,17S)-3-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-6,17-diol

: 155625-22-2
17β-acetoxy-3-methoxy-6,7-secoestra-1,3,5(10)-triene-6,7-dioic acid 7-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / toluene / 5 h / Heating

2: pyridine / 18 h

3: 88 percent / NaIO₄, KMnO₄ / acetone; H₂O / 96 h

4: 100 percent / DCC / diethyl ether; CHCl₃ / 6 h

5: 1.) NaOMe, 2.) pyridine, acetic anhydride / 1.) 2 h, 2.) 22 h

With pyridine; potassium permanganate; sodium periodate; sodium methylate; acetic anhydride; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In diethyl ether; chloroform; water; acetone; toluene;