Technology Process of 17β-acetoxy-3-methoxy-6,7-secoestra-1,3,5(10)-triene-6,7-dioic acid 6-methyl ester
There total 6 articles about 17β-acetoxy-3-methoxy-6,7-secoestra-1,3,5(10)-triene-6,7-dioic acid 6-methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaBH4, 2.) 10percent aq. HCl / ethanol / 20 h
2: p-TsOH / toluene / 5 h / Heating
3: pyridine / 18 h
4: 88 percent / NaIO4, KMnO4 / acetone; H2O / 96 h
5: 100 percent / DCC / diethyl ether; CHCl3 / 6 h
6: 1.) NaOMe, 2.) pyridine, acetic anhydride / 1.) 2 h, 2.) 22 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; potassium permanganate; sodium periodate; sodium methylate; acetic anhydride; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide;
In
diethyl ether; ethanol; chloroform; water; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / 18 h
2: 88 percent / NaIO4, KMnO4 / acetone; H2O / 96 h
3: 100 percent / DCC / diethyl ether; CHCl3 / 6 h
4: 1.) NaOMe, 2.) pyridine, acetic anhydride / 1.) 2 h, 2.) 22 h
With
pyridine; potassium permanganate; sodium periodate; sodium methylate; acetic anhydride; dicyclohexyl-carbodiimide;
In
diethyl ether; chloroform; water; acetone;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / NaIO4, KMnO4 / acetone; H2O / 96 h
2: 100 percent / DCC / diethyl ether; CHCl3 / 6 h
3: 1.) NaOMe, 2.) pyridine, acetic anhydride / 1.) 2 h, 2.) 22 h
With
pyridine; potassium permanganate; sodium periodate; sodium methylate; acetic anhydride; dicyclohexyl-carbodiimide;
In
diethyl ether; chloroform; water; acetone;
