6-Hydroxy-4-thiahexanoic acid 1,6-lactone

Base Information

• Chemical Name: 6-Hydroxy-4-thiahexanoic acid 1,6-lactone
• CAS No.: 5512-72-1
• Molecular Formula: C₅H₈O₂S
• Molecular Weight: 132.183
• Mol file: 5512-72-1.mol

Synonyms:1,4-Oxathiepan-7-one;6-Hydroxy-4-thiahexanoic acid 1,6-lactone

Chemical Property of 6-Hydroxy-4-thiahexanoic acid 1,6-lactone

Chemical Property:

• PSA: 51.60000
• LogP: 0.66650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Hydroxy-4-thiahexanoic acid 1,6-lactone

There total 3 articles about 6-Hydroxy-4-thiahexanoic acid 1,6-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,6-dihydroxy-3-thiahexane (5323-60-4) → 1,4-oxathiepan-7-one (5512-72-1) + C5H8O2S (4385-34-6)

Guidance literature:

With 2,4,6-trimethyl-pyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 4h; regioselective reaction;

DOI:10.2174/157017809789124849

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) → 1,4-oxathiepan-7-one (5512-72-1)

Guidance literature:

With β‐cyclodextrin; at 24 ℃; for 24h; chemoselective reaction; neat (no solvent);

DOI:10.1002/ejoc.200700872

Reference yield:

p-nitrophenyl acrylate (2123-85-5) + 2-hydroxyethanethiol (60-24-2) → 1,4-oxathiepan-7-one (5512-72-1)

Guidance literature:

With potassium carbonate; triethylamine;

DOI:10.3390/molecules25030687

upstream raw materials:

Tetrahydrothiopyran-4-one

1,6-dihydroxy-3-thiahexane

p-nitrophenyl acrylate

2-hydroxyethanethiol