Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate

Base Information

• Chemical Name: Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate
• CAS No.: 51814-17-6
• Molecular Formula: C17H23NO6
• Molecular Weight: 337.373
• Hs Code.: 2922509090
• Mol file: 51814-17-6.mol

Synonyms:Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate;3-[(N-benzyloxycarbonylethoxycarbonyl)methylamino]propanoic acid ethyl ester;Ethyl 3-[(N-benzyloxycarbonylethoxycarbonyl)methylamino]propanoate

Chemical Property of Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate

Chemical Property:

• Boiling Point: 445.3±45.0 °C(Predicted)
• PKA: -1.87±0.70(Predicted)
• PSA: 82.14000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 2.14150

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate

There total 5 articles about Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

glycine ethyl ester hydrochloride (623-33-6) + benzyl chloroformate (501-53-1,94274-21-2) → ethyl N-benzoxycarbonyl-N-(2-ethoxcarbonylethyl)glycinate (51814-17-6)

Guidance literature:

glycine ethyl ester hydrochloride; ethyl acrylate; With triethylamine; In ethanol; at 80 ℃; for 1h;

benzyl chloroformate; With sodium carbonate; In water; acetone; at 0 - 20 ℃; for 2h;

Reference yield: 80.0%

diethyl 2-azabutane-1,4-dicarboxylate (3783-61-7) + benzyl chloroformate (501-53-1,94274-21-2) → ethyl N-benzoxycarbonyl-N-(2-ethoxcarbonylethyl)glycinate (51814-17-6)

Guidance literature:

In acetonitrile; at 0 ℃; for 1h;

DOI:10.1139/v00-043

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + benzyl chloroformate (501-53-1,94274-21-2) + ethyl acrylate (140-88-5,9003-32-1) → ethyl N-benzoxycarbonyl-N-(2-ethoxcarbonylethyl)glycinate (51814-17-6)

Guidance literature:

glycine ethyl ester hydrochloride; With triethylamine; In ethanol;

ethyl acrylate; In ethanol; at 0 - 25 ℃; for 24h;

benzyl chloroformate; In ethanol; at 0 - 25 ℃; for 2h;

upstream raw materials:

diethyl 2-azabutane-1,4-dicarboxylate

benzyl chloroformate

Ethyl 3-bromopropionate

glycine ethyl ester hydrochloride

Downstream raw materials:

(2R,3S,1'S,2'S)-N-benzoxycarbonyl-2-(1'-hydroxy-2'-thiophenyl-3'-butenyl)-3-methoxymethyloxypyrrolidine

(2R,3S,1'R)-N-benzoxycarbonyl-2-(1',4'-dihydroxy-2'butenyl)-3-methoxymethyloxypyrrolidine

ethyl (2R,3S)-N-benzoxycarbonyl-3-methoxymethyloxypyrrolidine-2-carboxylate

(2R,3S)-N-benzoxycarbonyl-3-hydroxymethyl-3-methoxymethyloxypyrrolidine