3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester

Base Information

• Chemical Name: 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester
• CAS No.: 51814-18-7
• Molecular Formula: C₁₅H₁₇NO₅
• Molecular Weight: 291.304
• Hs Code.: 2933998090

Synonyms:3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester

Chemical Property of 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-Oxopyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester ^*data from reagent suppliers

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Technology Process of 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester

There total 4 articles about 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl N-benzoxycarbonyl-N-(2-ethoxcarbonylethyl)glycinate (51814-17-6) → 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester (51814-18-7)

Guidance literature:

With potassium tert-butylate; In toluene; at 0 ℃; for 0.5h;

DOI:10.1139/v00-043

Reference yield:

diethyl 2-azabutane-1,4-dicarboxylate (3783-61-7) → 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester (51814-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetonitrile / 1 h / 0 °C

2: t-BuOK / toluene / 0.5 h / 0 °C

With potassium tert-butylate; In toluene; acetonitrile; 1: Condensation / 2: Dickemann cyclization;

DOI:10.1139/v00-043

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester (51814-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetonitrile / 1 h / 0 °C

2: t-BuOK / toluene / 0.5 h / 0 °C

With potassium tert-butylate; In toluene; acetonitrile; 1: Condensation / 2: Dickemann cyclization;

DOI:10.1139/v00-043

upstream raw materials:

ethyl N-benzoxycarbonyl-N-(2-ethoxcarbonylethyl)glycinate

diethyl 2-azabutane-1,4-dicarboxylate

benzyl chloroformate

Downstream raw materials:

ethyl (2R,3S)-N-benzoxycarbonyl-3-hydroxypyrrolidine-2-carboxylate

(2R,3S)-N-benzoxycarbonyl-3-methoxymethyloxypyrrolidine-2-carboxaldehyde

(2R,3S)-N-benzoxycarbonyl-3-hydroxymethyl-3-methoxymethyloxypyrrolidine

ethyl (2R,3S)-N-benzoxycarbonyl-3-methoxymethyloxypyrrolidine-2-carboxylate

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