Technology Process of 2,6-Dichloro-4-iodobenzoic acid
There total 5 articles about 2,6-Dichloro-4-iodobenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-dichloro-4-iodo-benzoic acid methyl ester;
With
pyridine; water; lithium iodide;
at 130 ℃;
for 30h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1,4-dioxane / 110 °C
2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 - 20 °C
3.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / Reflux
4.1: sulfuric acid / ethyl acetate / 2 h / 20 °C
5.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 - 0 °C / Cooling with ice/alcohol
5.2: 0 - 20 °C
6.1: water; lithium iodide / pyridine / 30 h / 130 °C
With
2,6-dimethylpyridine; hydrogenchloride; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; triethylamine; lithium iodide; sodium nitrite;
palladium diacetate;
In
1,4-dioxane; pyridine; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / Reflux
2.1: sulfuric acid / ethyl acetate / 2 h / 20 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 - 0 °C / Cooling with ice/alcohol
3.2: 0 - 20 °C
4.1: water; lithium iodide / pyridine / 30 h / 130 °C
With
hydrogenchloride; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; triethylamine; lithium iodide; sodium nitrite;
palladium diacetate;
In
pyridine; water; ethyl acetate; N,N-dimethyl-formamide;
