(3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester
• CAS No.: 155891-93-3
• Molecular Formula: C₁₁H₁₃Cl₂NO₃
• Molecular Weight: 278.135
• Mol file: 155891-93-3.mol

Synonyms:(3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester

Chemical Property of (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(3,5-Dichloro-4-hydroxy-phenyl)-carbamicacidtert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester

There total 3 articles about (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-amino-2,6-dichlorophenol (5930-28-9) → (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester (155891-93-3)

Guidance literature:

In tetrahydrofuran; for 2.5h; Heating / reflux;

Reference yield: 93.0%

di-tert-butyl oxalate (691-64-5) + 4-amino-2,6-dichlorophenol (5930-28-9) → (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester (155891-93-3)

Guidance literature:

In tetrahydrofuran; for 2.5h; Reflux; Inert atmosphere;

DOI:10.1021/jm800824d

Reference yield:

tert-butyldicarbonate (34619-03-9) + 4-amino-2,6-dichlorophenol (5930-28-9) → (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester (155891-93-3)

Guidance literature:

In tetrahydrofuran; for 15h; Heating / reflux;

upstream raw materials:

tert-butyldicarbonate

4-amino-2,6-dichlorophenol

di-tert-butyl dicarbonate

di-tert-butyl oxalate

Downstream raw materials:

trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester

3,5-dichloro-4-(3'-iso-propyl-4'-methoxyphenoxy)phenylcarbamic acid tert-butyl ester

4-tert-butoxycarbonylamino-2,6-dichloro-benzoic acid methyl ester

[3,5-dichloro-4-(4'-hydroxy-3'-isopropylphenoxy)phenylamino]methylphosphonic acid