5-BROMO-BETA-OXO-2-THIOPHENEPROPANOIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-BROMO-BETA-OXO-2-THIOPHENEPROPANOIC ACID METHYL ESTER
• CAS No.: 137090-42-7
• Molecular Formula: C8H7BrO3S
• Molecular Weight: 263.112
• Mol file: 137090-42-7.mol

Synonyms:5-BROMO-BETA-OXO-2-THIOPHENEPROPANOIC ACID METHYL ESTER

Chemical Property of 5-BROMO-BETA-OXO-2-THIOPHENEPROPANOIC ACID METHYL ESTER

Chemical Property:

• PSA: 71.61000
• LogP: 2.25640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-BETA-OXO-2-THIOPHENEPROPANOIC ACID METHYL ESTER

There total 3 articles about 5-BROMO-BETA-OXO-2-THIOPHENEPROPANOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Acetyl-5-bromothiophene (5370-25-2) + carbonic acid dimethyl ester (616-38-6) → methyl 3-(5-bromothiophen-2-yl)-3-oxopropionate (137090-42-7)

Guidance literature:

2-Acetyl-5-bromothiophene; carbonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; water; pH=3;

Reference yield: 92.3%

5-bromothiophene-2-carboxylic acid (7311-63-9) + monomethyl monopotassium malonate (38330-80-2) → methyl 3-(5-bromothiophen-2-yl)-3-oxopropionate (137090-42-7)

Guidance literature:

5-bromothiophene-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 ℃;

monomethyl monopotassium malonate; With magnesium chloride; at 20 ℃; for 18h;

Reference yield: 78.0%

→ methyl 3-(5-bromothiophen-2-yl)-3-oxopropionate (137090-42-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 70 ℃; for 2h; Inert atmosphere; Cooling with ice;

upstream raw materials:

2-Acetyl-5-bromothiophene

carbonic acid dimethyl ester

5-bromothiophene-2-carboxylic acid

monomethyl monopotassium malonate

Downstream raw materials:

{1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetic acid

methyl {1-(2-chlorophenyl)-5-[5-(3-methanesulfonylphenyl)thiophen-2-yl]-1H-pyrazol-3-yloxy}acetate

[5-(5-bromothiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yloxy]acetic acid methyl ester

C₁₄H₁₀BrClN₂OS

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE". Page/Page column 80. . Retrieved 2010/06/20.
• 2、 Hulin, Bernard,Clark, David A.,Goldstein, Steven W.,McDermott, Ruth E.,Dambek, Paul J.,et al.. "Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents". . p. 1853 - 1864. Retrieved 2007/10/02.