7311-63-9Relevant academic research and scientific papers
Combining photoredox catalysis and oxoammonium cations for the oxidation of aromatic alcohols to carboxylic acids
Nandi, Jyoti,Hutcheson, Ellen L.,Leadbeater, Nicholas E.
supporting information, (2020/12/25)
A methodology is reported for converting alcohols to the corresponding carboxylic acids. A dual catalytic system involving a merger of photoredox catalysis and 4-acetamido-TEMPO is employed to carry out this oxidation process.
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
Zhan, Wenhu,Che, Jinxin,Xu, Lei,Wu, Yizhe,Hu, Xiaobei,Zhou, Yubo,Cheng, Gang,Hu, Yongzhou,Dong, Xiaowu,Li, Jia
supporting information, p. 72 - 85 (2019/07/12)
A series of pyrazole-thiophene derivatives exhibiting good Akt inhibitory activities were obtained on the basis of conformational restriction strategy, leading to the discovery of compound 1d and 1o which showed excellent in vitro antitumor effect against a variety of hematologic cancer cells and their potential of inducing apoptosis, blocking the cell cycles at S phase and significantly inhibiting the phosphorylation of downstream biomarkers of Akt kinase of cancer cells. Amongst, compound 1o also exhibited good PK profiles and inhibited about 40% tumor growth in MM1S xenograft model. Compound 1o might be a potential candidate for further development.
Effect of alkyl chain and linking units on mesophase transitions and molecular order of rod-like thiophene mesogens: 13C NMR investigation
Santhosh Kumar Reddy,Lobo, Nitin P.,Narasimhaswamy
supporting information, p. 598 - 612 (2017/12/28)
Thermotropic liquid crystals with π-conjugated cores are increasingly witnessed due to their promising optoelectronic and optophotonic properties. As π-conjugated mesogens are often realized by direct linking of the rings of the core, the mesophase transitions are usually modulated by inserting the required alkyl/alkoxy chains either at a terminal or lateral location. In this work, five mesogens in which thiophene and two phenyl rings are common in the core unit with terminal alkyl/alkoxy chains are investigated to probe the influence of (a) a terminal alkyl chain on the mesophase characteristics, (b) the linking units on the mesophase range and (c) the disparity of thiophene orientational constraints. The mesophase properties reveal that whenever the alkyl chain is located at one end of the molecule, polymesomorphism is observed. The XRD studies reveal layer ordering typical of smectic mesophases with lower temperature and higher order phases, namely SmB and CrE phases. A detailed 13C NMR study of the mesogens in the liquid crystalline phase indicates that the order parameters are governed by the nature of the substitution of thiophene and its linkage with two phenyl rings. Importantly, the 13C NMR data of the terminal chains in the liquid crystalline phase are compared with the recently reported thiophene mesogen in which the n-hexyl chain is located at the lateral position and completely different orientation characteristics were found for the terminal versus lateral chains.
New iridium-containing conjugated polymers for polymer solar cell applications
Keshtov,Kuklin,Konstantinov,Chen, Fang-Chung,Xie, Zhi-yuan,Sharma, Ganesh D.
, p. 17296 - 17302 (2018/11/01)
A series of novel donor-acceptor (D-A) copolymers P1-P5 with iridium-complexed moieties in their side chains have been synthesized on the basis of a new iridium-containing monomer. The results obtained show that P1-P5 have good thermal stability (317-347 °C) for photovoltaic applications. These copolymers absorb visible light in a broad spectral range up to 680 nm. The optical bandgaps of P1-P5 are in the range of 1.96-2.08 eV, respectively. The HOMO and LUMO energy levels of the polymers P1-P5 estimated from cyclic voltammetry measurements indicate that these copolymers are suitable as electron donors along with PC71BM as an electron acceptor for bulk heterojunction polymer solar cells. BHJ polymer solar cells were developed based on blend compositions (P1-P5):PC71BM. The values of Jsc, Voc, and FF are in the range of 0.95-4.44 mA cm?2, 0.67-0.69 V and 34.6-56.8%, and the power conversion efficiencies (PCE) are in the range of 0.22-1.74%, respectively, the highest value of 1.74% being for P3. Increase of the photovoltaic parameters was achieved with increasing iridium complex percentage in the polymers due to involvement of triplet effects. The improvement in the efficiency of the triplet-forming polymers P2 and P3 in comparison with P1 appears to be due to the formation of triplet excitons in comparison with singlet excitons in the polymer P1 which does not contain heavy metals. With further increase in the content of iridium complex fragments in the polymers, for example, up to 3 mol% for polymer P4, the efficiency falls to 1.23% and further decreased to 0.22% for P5.
Structure–Activity Relationship of Propargylamine-Based HDAC Inhibitors
Wünsch, Matthias,Senger, Johanna,Schultheisz, Philipp,Schwarzbich, Sabrina,Schmidtkunz, Karin,Michalek, Carmela,Kla?, Michaela,Goskowitz, Stefanie,Borchert, Philipp,Praetorius, Lucas,Sippl, Wolfgang,Jung, Manfred,Sewald, Norbert
supporting information, p. 2044 - 2053 (2017/12/07)
As histone deacetylases (HDACs) play an important role in the treatment of cancer, their selective inhibition has been the subject of various studies. These continuous investigations have given rise to a large collection of pan- and selective HDAC inhibitors, containing diverse US Food and Drug Administration (FDA)-approved representatives. In previous studies, a class of alkyne-based HDAC inhibitors was presented. We modified this scaffold in two previously neglected regions and compared their cytotoxicity and affinity toward HDAC1, HDAC6, and HDAC8. We were able to show that R-configured propargylamines contribute to increased selectivity for HDAC6. Docking studies on available HDAC crystal structures were carried out to rationalize the observed selectivity of the compounds. Substitution of the aromatic portion by a thiophene derivative results in high affinity and low cytotoxicity, indicating an improved drug tolerance.
Palladium catalyzed reactions executed on solid-phase peptide synthesis supports for the production of self-assembling peptides embedded with complex organic electronic subunits
-
, (2016/02/03)
Methods to synthesize self-assembling peptides embedded with complex organic electronic subunits are provided.
Is carbon dioxide able to activate halogen/lithium exchange?
Durka, Krzysztof,Lulinski, Sergiusz,Dabrowski, Marek,Serwatowski, Janusz
, p. 4562 - 4570 (2014/08/05)
The unexpected effect of carbon dioxide on halogen-lithium exchange (HLE) reactions of selected haloarenes with tBuLi was investigated. In an aliphatic hydrocarbon solvent (pentane), the HLE does not occur at ca. -70 C but, surprisingly, pouring the mixture of reactants onto dry ice and subsequent aqueous acidic hydrolysis gave carboxylic acids resulting from the quench of the first-formed aryllithiums with carbon dioxide. This suggests that CO 2 acts as a promoter of the HLE and, subsequently, serves as an electrophile to trap the aryllithium intermediates that are generated in situ. Theoretical DFT calculations were used to develop a plausible mechanism for the reaction, which indicates that CO2 is a much weaker donor than tetrahydrofuran (THF) so the cleavage of inert tBuLi cubic tetramers into more reactive solvated dimeric species (tBuLi)2(CO2) 4 is disfavored by 42.8 kJ per mol of (tBuLi)4. It is possible that this deaggregation process occurs to some extent when a large excess of CO2 is used. Copyright
Palladium Catalyzed Reactions Executed on Solid-Phase Peptide Synthesis Supports for the Production of Self-Assembling Peptides Embedded with Complex Organic Electronic Subunits
-
Page/Page column, (2014/05/07)
Methods to synthesize self-assembling peptides embedded with complex organic electronic subunits are provided.
D-π-A structured porphyrins for efficient dye-sensitized solar cells
Lu, Jianfeng,Xu, Xiaobao,Cao, Kun,Cui, Jin,Zhang, Yibo,Shen, Yan,Shi, Xiaobo,Liao, Liangsheng,Cheng, Yibing,Wang, Mingkui
, p. 10008 - 10015 (2013/09/02)
In this study, new push-pull alkoxy-wrapped zinc porphyrin dyes with intramolecular donor-π-acceptor structures have been designed and synthesized for dye-sensitized solar cells (DSCs). The linkers based on thiophene or 2,3-dihydrothieno[3,4-b][1,4] dioxine with cyanoacetic acid can broaden the spectral response of porphyrins into the near-IR region (～850 nm), which is mainly attributed to the cyanoacetic acid group. However, porphyrins with cyanoacrylic acid as an anchoring group lead to a faster charge recombination rate at the dye-sensitized heterojunction interface, which lowers the device photovoltaic performance. By using porphyrins with a rigid π-linker feature structure that is 5-ethynylthiophene-2-carboxylic acid, highly efficient DSC devices with a power conversion efficiency of 9.5% can be obtained. Spectral, electrochemical, photovoltage transient decay and impedance measurements are performed to reveal the influence of π-conjugated linkers and anchoring groups upon the optoelectronic features of porphyrin dyes in DSCs.
OXAZOLE AND ISOXAZOLE CRAC MODULATORS
-
Page/Page column 72, (2012/05/19)
The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).
