Ethyl 3-bromo-4-iodobenzoate

Base Information

• Chemical Name: Ethyl 3-bromo-4-iodobenzoate
• CAS No.: 386267-31-8
• Molecular Formula: C9H8BrIO2
• Molecular Weight: 354.96709
• Mol file: 386267-31-8.mol

Synonyms:Ethyl 3-bromo-4-iodobenzoate

Chemical Property of Ethyl 3-bromo-4-iodobenzoate

Chemical Property:

• Boiling Point: 341.4±27.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.949±0.06 g/cm3(Predicted)
• LogP: 3.23040
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-bromo-4-iodobenzoate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-bromo-4-iodobenzoate

There total 3 articles about Ethyl 3-bromo-4-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 3-bromo-4-aminobenzoate (7149-03-3) → ethyl 3-bromo-4-iodobenzoate (386267-31-8)

Guidance literature:

ethyl 3-bromo-4-aminobenzoate; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

With potassium iodide; In water; at 0 - 20 ℃; for 2.25h;

DOI:10.1021/jacs.6b10816

Reference yield:

p-aminoethylbenzoate (94-09-7) → ethyl 3-bromo-4-iodobenzoate (386267-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 55 percent / Br₂ / CH₂Cl₂ / 12 h / 20 °C

2.1: NaNO₂; aq. HCl / 3 h / 20 °C

2.2: 63 percent / aq. KI / 12 h / 20 °C

With hydrogenchloride; bromine; sodium nitrite; In dichloromethane;

DOI:10.1055/s-2001-18066

Reference yield:

p-aminoethylbenzoate (94-09-7) → ethyl 3-bromo-4-iodobenzoate (386267-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / chloroform / 3 h / 0 °C / Inert atmosphere

2.1: sulfuric acid; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; sodium nitrite; In chloroform; water;

DOI:10.1002/anie.201106734

upstream raw materials:

ethyl 3-bromo-4-aminobenzoate

p-aminoethylbenzoate