N-Boc-3-Methylpiperidin-4-one

Base Information

• Chemical Name: N-Boc-3-Methylpiperidin-4-one
• CAS No.: 374794-77-1
• Molecular Formula: C11H19NO3
• Molecular Weight: 213.277
• Mol file: 374794-77-1.mol

Synonyms:N-Boc-3-Methylpiperidin-4-one;4-Methyl-3-oxo-1-piperidinecarboxylic acid tert-butyl ester;4-Methyl-3-oxo-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-methyl-3-oxo-, 1,1-dimethylethyl ester

Chemical Property of N-Boc-3-Methylpiperidin-4-one

Chemical Property:

• Boiling Point: 298.8±33.0 °C(Predicted)
• PKA: -1.67±0.40(Predicted)
• PSA: 46.61000
• Density: 1.060
• LogP: 1.77030

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-3-Methylpiperidin-4-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-3-Methylpiperidin-4-one

There total 8 articles about N-Boc-3-Methylpiperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

1-benzyl-4-methyl-piperidin-3-one (32018-96-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate (374794-77-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield: 99.0%

trans-(RS)-1,1-dimethylethyl 3-hydroxy-4-methylpiperidinecarboxylate (1188264-78-9,374794-75-9,955028-75-8) → tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate (374794-77-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 86.0%

4-methylpyridin-3-ol (1121-19-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate (374794-77-1)

Guidance literature:

4-methylpyridin-3-ol; di-tert-butyl dicarbonate; for 10h; Reflux;

With sodium tetrahydroborate; at 0 ℃; for 2h;

upstream raw materials:

trans-(RS)-1,1-dimethylethyl 3-hydroxy-4-methylpiperidinecarboxylate

1-benzyl-4-methyl-piperidin-3-one

di-tert-butyl dicarbonate

1-benzyl-3-oxopiperidine-4-carboxylic acid methyl ester

Downstream raw materials:

(RS)-3,3-Difluoro-4-methylpiperidine Hydrochloride

(3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester

(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

(3R,4R)-3-amino-4-methylpiperidine-1-carboxylic acid tert-butyl ester