3,4-bis-(hydroxyMethyl)-pyridine

Base Information

• Chemical Name: 3,4-bis-(hydroxyMethyl)-pyridine
• CAS No.: 38070-80-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.15186
• Hs Code.: 2933399090
• Mol file: 38070-80-3.mol

Synonyms:3,4-bis-(hydroxyMethyl)-pyridine;3,4-PyridinediMethanol;[4-(hydroxymethyl)pyridin-3-yl]methanol

Chemical Property of 3,4-bis-(hydroxyMethyl)-pyridine

Chemical Property:

• Melting Point: 144 °C
• Boiling Point: 344.4±32.0 °C(Predicted)
• PKA: 13.48±0.10(Predicted)
• PSA: 53.35000
• Density: 1.261±0.06 g/cm3(Predicted)
• LogP: 0.06620
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3,4-Pyridinedimethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3,4-bis-(hydroxyMethyl)-pyridine

There total 7 articles about 3,4-bis-(hydroxyMethyl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethyl pyridine-3,4-dicarboxylate (1678-52-0) → [3-(hydroxymethyl)-4-pyridyl]methanol (38070-80-3)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 80 ℃;

Reference yield: 85.0%

dimethyl 3,4-pyridinedicarboxylate (1796-83-4) → [3-(hydroxymethyl)-4-pyridyl]methanol (38070-80-3)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In ethanol; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00443

Reference yield:

3,4-pyridinecarboxylic acid (490-11-9) → [3-(hydroxymethyl)-4-pyridyl]methanol (38070-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄ / 20 h / Heating

2: NaBH₄ / ethanol / 17 h / Heating

With sodium tetrahydroborate; sulfuric acid; In ethanol;

DOI:10.1016/S0968-0896(02)00426-1

upstream raw materials:

3,4-bis(chloromethyl)pyridine

diethyl pyridine-3,4-dicarboxylate

dimethyl 3,4-pyridinedicarboxylate

3,4-pyridinecarboxylic acid

Downstream raw materials:

3,4-bis(chloromethyl)pyridine

2-(4-nitrophenyl)sulfonyl-1,3-dihydropyrrolo[3,4-c]pyridine

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