4-AMino-5-Methylisophthalonitrile

Base Information

• Chemical Name: 4-AMino-5-Methylisophthalonitrile
• CAS No.: 98589-70-9
• Molecular Formula: C₉H₇N₃
• Molecular Weight: 157.175
• Hs Code.: 2922390090
• Mol file: 98589-70-9.mol

Synonyms:4-AMino-5-Methylisophthalonitrile

Chemical Property of 4-AMino-5-Methylisophthalonitrile

Chemical Property:

• PSA: 73.60000
• LogP: 1.90176

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-5-methylisophthalonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMino-5-Methylisophthalonitrile

There total 7 articles about 4-AMino-5-Methylisophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-methyl-4,6-dichloroaniline (30273-00-8) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → 4-amino-5-methylisophthalonitrile (98589-70-9)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-ethyl-N,N-diisopropylamine; XPhos; In butan-1-ol; at 80 ℃; for 3h; Inert atmosphere;

Reference yield: 78.0%

2,4-dibromo-6-methylaniline (30273-41-7) + potassium ferrocyanide → 4-amino-5-methylisophthalonitrile (98589-70-9)

Guidance literature:

With sodium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 150 ℃; for 18h; Reagent/catalyst; Temperature;

Reference yield: 73.0%

2,4-dibromo-6-methylaniline (30273-41-7) + copper(l) cyanide → 4-amino-5-methylisophthalonitrile (98589-70-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 6h; Temperature;

upstream raw materials:

o-toluidine

2,4-dibromo-6-methylaniline

sodium cyanide

2-methyl-4,6-dichloroaniline