30273-00-8

Basic information

• Product Name: 2,4-DICHLORO-6-METHYLANILINE
• Synonyms: TIMTEC-BB SBB003781;2,4-DICHLORO-6-METHYLANILINE;4,6-Dichloro-o-toluidine;2,4-DICHLORO-6-METHYLANILINE 97%;2-amino-3,5-dichlorotoluene;2-Amino-3,5-dichlorotoluene, 4,6-Dichloro-o-toluidine
• CAS NO: 30273-00-8
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04
• EINECS: -0
• Mol File: 30273-00-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 42-46 °C(lit.)
• Boiling Point: 82-84°C 0,1mm
• Flash Point: >230 °F
• Appearance: /
• Density: 1.334 g/cm³
• Vapor Pressure: 0.0101mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.87±0.10(Predicted)
• BRN: 2208221
• CAS DataBase Reference: 2,4-DICHLORO-6-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-6-METHYLANILINE(30273-00-8)
• EPA Substance Registry System: 2,4-DICHLORO-6-METHYLANILINE(30273-00-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 30273-00-8(Hazardous Substances Data)

Usage

Uses

2,4-Dichloro-6-methylaniline, can be used as an aniline moiety containing compound, for the synthesis of more complex pharmaceutical compounds , such as 4-Chloro-dasatinib (C364915).

InChI:InChI=1/C7H7Cl2N/c1-4-2-5(8)3-6(9)7(4)10/h2-3H,10H2,1H3

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 95-53-4 o-toluidine 
• 5202-86-8 4-chloro-2-methylacetanilide 
• 118665-00-2 2,4-dichloro-6-methylnitrobenzene 
• 61655-97-8 2,4-dichloro-6-methylacetanilide 
• 120-66-1 N-(2-methylphenyl)acetamide 

Downstream Products

• 25186-47-4 3,5-dichlorotoluene 
• 56961-86-5 2,3,5-trichloro-toluene 
• 876493-68-4 2-bromo-3,5-dichloro-toluene 
• 175277-98-2 2,4-dichloro-6-methyl-benzonitrile 
• 444325-49-9 chloro-acetic acid-(2,4-dichloro-6-methyl-anilide) 
• 56106-67-3 2-methyl-4,6-dichloro-N-methylbenzenamine 
• 57837-16-8 2-(2,4-Dichloro-6-methyl-phenylamino)-propionic acid methyl ester 
• 1022250-21-0 N-(2,4-dichloro-6-methylphenyl)-7-(1-ethylpropyl)-4-methoxy-1-methyl-1H-benzimidazol-2-amine 
• 1022249-79-1 4-chloro-N-(2,4-dichloro-6-methylphenyl)-7-(1-ethylpropyl)-1H-benzimidazol-2-amine 
• 890707-28-5 2-amino-3-methyl-5-chlorobenzoyl-N-methylamine 
• 20776-67-4 2-amino-5-chloro-3-methylbenzoic acid 
• 939990-03-1 2-amino-5-chloro-3-methylbenzonitrile 
• 98589-70-9 4-amino-5-methylisophthalonitrile 
• 890707-29-6 2-amino-3-methyl-5-cyanobenzoyl-N-methylamine 

Relevant articles and documents

Synthetic method of chlorantraniliprole pesticide intermediate 2 - amino -5 - chlorine - N and 3 -dimethylbenzamide

The invention relates to a synthetic method of a chlorantraniliprole pesticide intermediate 2 - amino -5 - chlorine - N and 3 -dimethylbenzamide. Chloro, formylation gave 2 - amino -5 - chloro - N, 3 - dimethyl. The method has the advantages of simple reaction, low cost and high yield, and is a method suitable for industrial production.

Cardiotonic Agents. Synthesis and Cardiovascular Properties of Novel 2-Arylbenzimidazoles and Azabenzimidazoles

Novel 2-arylbenzimidazoles and azabenzimidazoles were synthesized, and their inotropic action was evaluated.Changes in left ventricular pressure, dP/dt max, were measured as an index of cardiac contractility.The structural features that impart optimal inotropic activity are presented.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers.To investigate the mechanism of action, the most potent compounds were tested for their calcium-sensitizing properties and their potential for the inhibition of phosphodiesterase.Two compounds, 1 and 41, showed interesting in vitro and oral activity without side effects.They have a more potent calcium-sensitizing effect than MCI-154 and are under further investigation.