30273-00-8

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DICHLORO-6-METHYLANILINE is used as an aniline moiety containing compound for the synthesis of more complex pharmaceutical compounds. It plays a crucial role in the production of drugs with potential therapeutic applications.
Specifically, it is used in the synthesis of 4-Chloro-dasatinib (C364915), a compound with potential anti-cancer properties. The presence of the aniline moiety in 2,4-DICHLORO-6-METHYLANILINE allows for the formation of various chemical bonds and reactions that are essential for creating the desired pharmaceutical compounds.

InChI:InChI=1/C7H7Cl2N/c1-4-2-5(8)3-6(9)7(4)10/h2-3H,10H2,1H3

Upstream product

• 120-66-1 N-(2-methylphenyl)acetamide 
• 61655-97-8 2,4-dichloro-6-methylacetanilide 
• 5202-86-8 4-chloro-2-methylacetanilide 
• 88-72-2 1-methyl-2-nitrobenzene 
• 95-53-4 o-toluidine 
• 118665-00-2 2,4-dichloro-6-methylnitrobenzene 

Downstream Products

• 56106-67-3 2-methyl-4,6-dichloro-N-methylbenzenamine 
• 57837-16-8 2-(2,4-Dichloro-6-methyl-phenylamino)-propionic acid methyl ester 
• 34857-52-8 C₁₂H₁₅Cl₃N₂O 
• 25186-47-4 3,5-dichlorotoluene 
• 444325-49-9 chloro-acetic acid-(2,4-dichloro-6-methyl-anilide) 
• 69278-43-9 1,3-Dichloro-5-(2-methyl-propenyl)-benzene 
• 69278-44-0 1,3-Dichloro-5-(2-methyl-allyl)-benzene 
• 87077-76-7 1-(3,5-Dichloro-phenyl)-2-methyl-propan-2-ol 
• 69278-41-7 1,3-Dichloro-5-(2-chloro-2-methyl-propyl)-benzene 
• 867058-64-8 2,6-diacetylpyridinebis(2,4-dichloro-6-methylphenylanil) 
• 890707-28-5 2-amino-3-methyl-5-chlorobenzoyl-N-methylamine 
• 20776-67-4 2-amino-5-chloro-3-methylbenzoic acid 
• 939990-03-1 2-amino-5-chloro-3-methylbenzonitrile 
• 7778-01-0 3,5-dichlorobenzyl bromide 

Relevant academic research and scientific papers

Synthetic method of chlorantraniliprole pesticide intermediate 2 - amino -5 - chlorine - N and 3 -dimethylbenzamide

The invention relates to a synthetic method of a chlorantraniliprole pesticide intermediate 2 - amino -5 - chlorine - N and 3 -dimethylbenzamide. Chloro, formylation gave 2 - amino -5 - chloro - N, 3 - dimethyl. The method has the advantages of simple reaction, low cost and high yield, and is a method suitable for industrial production.

2-amino-5-chloro-N,3-dimethylbenzamide preparation method

The invention discloses a 2-amino-5-chloro-N,3-dimethylbenzamide preparation method, which comprises: carrying out a chlorination reaction a raw material represented by a formula I and a chlorinationreagent at the ortho-position and the para-position of amino to generate a compound represented by a formula II, carrying out a selective substitution reaction on the compound represented by the formula II and a cyano group mainly based on amino o-chlorine substitution under an alkaline catalysis condition by utilizing the thermodynamic stability difference between the o-chlorine and the p-chlorine of amino to generate a compound represented by a formula III, hydrolyzing the compound represented by the formula III into a compound represented by a formula IV, esterifying the compound represented by the formula IV to generate a compound represented by a formula V, and carrying out a reaction on the compound represented by the formula V and a monomethylamine methanol solution to generate 2-amino-5-chloro-N,3-dimethylbenzamide. According to the invention, the preparation method is high in yield, simple in reaction and small in toxic and side effects.

Cardiotonic Agents. Synthesis and Cardiovascular Properties of Novel 2-Arylbenzimidazoles and Azabenzimidazoles

Novel 2-arylbenzimidazoles and azabenzimidazoles were synthesized, and their inotropic action was evaluated.Changes in left ventricular pressure, dP/dt max, were measured as an index of cardiac contractility.The structural features that impart optimal inotropic activity are presented.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers.To investigate the mechanism of action, the most potent compounds were tested for their calcium-sensitizing properties and their potential for the inhibition of phosphodiesterase.Two compounds, 1 and 41, showed interesting in vitro and oral activity without side effects.They have a more potent calcium-sensitizing effect than MCI-154 and are under further investigation.