Benzaldehyde, 3-broMo-5-chloro-2-fluoro-

Base Information

• Chemical Name: Benzaldehyde, 3-broMo-5-chloro-2-fluoro-
• CAS No.: 1269440-82-5
• Molecular Formula: C7H3BrClFO
• Molecular Weight: 237.456
• Hs Code.: 2913000090
• Mol file: 1269440-82-5.mol

Synonyms:Benzaldehyde, 3-broMo-5-chloro-2-fluoro-;Benzaldehyde, 3-broMo-5-chloro-2-fluoro-2

Chemical Property of Benzaldehyde, 3-broMo-5-chloro-2-fluoro-

Chemical Property:

• Boiling Point: 261.3±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.779±0.06 g/cm3(Predicted)
• LogP: 3.05410

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-chloro-2-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde, 3-broMo-5-chloro-2-fluoro-

There total 2 articles about Benzaldehyde, 3-broMo-5-chloro-2-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-4-chloro-1-fluorobenzene (1996-30-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-bromo-5-chloro-2-fluorobenzaldehyde (1269440-82-5)

Guidance literature:

2-bromo-4-chloro-1-fluorobenzene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -75 - -65 ℃; for 0.833333h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -70 - -65 ℃; for 1.25h;

With hydrogenchloride; ammonium chloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; at -60 - -10 ℃; pH=1 - 2;

Reference yield:

2-bromo-4-chloro-1-fluorobenzene (1996-30-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-6-chloro-3-fluorobenzaldehyde (1242156-97-3) + 3-bromo-5-chloro-2-fluorobenzaldehyde (1269440-82-5)

Guidance literature:

2-bromo-4-chloro-1-fluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -75 ℃; Inert atmosphere; magnetically driven agitation in a tube;

N,N-dimethyl-formamide; In tetrahydrofuran; hexanes; at -75 - -20 ℃; regioselective reaction; Inert atmosphere; magnetically driven agitation in a tube;

DOI:10.1021/jo102275n

Reference yield: 97.5%

3-bromo-5-chloro-2-fluorobenzaldehyde (1269440-82-5) → 3-bromo-5-chloro-2-fluorobenzoic acid (1269232-93-0)

Guidance literature:

3-bromo-5-chloro-2-fluorobenzaldehyde; With potassium permanganate; In water; tert-butyl alcohol; at 40 - 60 ℃; for 2.5h;

With sodium carbonate; In water; tert-butyl alcohol; at 50 ℃; for 1h;

With hydrogenchloride; In tert-Amyl alcohol; water; pH=1;

upstream raw materials:

2-bromo-4-chloro-1-fluorobenzene

N,N-dimethyl-formamide

Downstream raw materials:

3-bromo-5-chloro-2-fluorobenzoic acid

tert-butyl 3-bromo-5-chloro-2-fluorophenyl-carbamate

3-bromo-5-chloro-2-fluoroaniline

tert-butyl 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate:

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