CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

Base Information

Chemical Name:CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester
CAS No.:1269440-69-8
Molecular Formula:C17H24BClFNO4
Molecular Weight:371.644
Hs Code.:
Mol file:1269440-69-8.mol

Synonyms:CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester;CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester-5

Suppliers and Price of CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

There total 4 articles about CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269232-94-1
tert-butyl 3-bromo-5-chloro-2-fluorophenyl-carbamate

: 73183-34-3
bis(pinacol)diborane

: 1269440-69-8
tert-butyl 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate:

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 16h; Product distribution / selectivity;

Reference yield:

: 1996-30-1
2-bromo-4-chloro-1-fluorobenzene

: 1269440-69-8
tert-butyl 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate:

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: diphenylphosphoranyl azide; triethylamine / toluene / 2 h / 75 - 84 °C

2.2: 0.25 h / 35 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diphenylphosphoranyl azide; potassium acetate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;

Reference yield:

: 1269232-93-0
3-bromo-5-chloro-2-fluorobenzoic acid

: 1269440-69-8
tert-butyl 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate:

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenylphosphoranyl azide; triethylamine / toluene / 2 h / 75 - 84 °C

1.2: 0.25 h / 35 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diphenylphosphoranyl azide; potassium acetate; triethylamine; In 1,4-dioxane; toluene;