4-(4-Trifluoromethylbenzoyl)piperidine

Base Information

Chemical Name:4-(4-Trifluoromethylbenzoyl)piperidine
CAS No.:149452-44-8
Molecular Formula:C13H14F3NO
Molecular Weight:257.254
Hs Code.:
DSSTox Substance ID:DTXSID20469832
Nikkaji Number:J3.536.004B
Mol file:149452-44-8.mol

Synonyms:4-(4-trifluoromethylbenzoyl)piperidine;149452-44-8;piperidin-4-yl-[4-(trifluoromethyl)phenyl]methanone;(PIPERIDIN-4-YL)(4-TRIFLUOROMETHYLPHENYL)METHANONE;SCHEMBL4240412;DTXSID20469832;FT-0711571

Suppliers and Price of 4-(4-Trifluoromethylbenzoyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-PIPERIDINYL[4-(TRIFLUOROMETHYL)PHENYL]METHANONE 95.00%
5MG
$ 498.74

Total 1 raw suppliers

Chemical Property of 4-(4-Trifluoromethylbenzoyl)piperidine

Chemical Property:

Boiling Point:334.0±42.0 °C(Predicted)
PKA:9?+-.0.10(Predicted)
PSA：29.10000
Density:1 +-.0.06 g/cm3(Predicted)
LogP:3.21650
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:257.10274856
Heavy Atom Count:18
Complexity:289

Purity/Quality:: 4-PIPERIDINYL[4-(TRIFLUOROMETHYL)PHENYL]METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1C(=O)C2=CC=C(C=C2)C(F)(F)F

Technology Process of 4-(4-Trifluoromethylbenzoyl)piperidine

There total 4 articles about 4-(4-Trifluoromethylbenzoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 25503-91-7
N-acetyl-4-piperidinecarbonitrile

: 149452-44-8
4-(4-trifluoromethylbenzoyl)piperidine

Guidance literature:

Reference yield:

: 213886-98-7
1-acetyl-N-methoxy-N-methylpiperidine-4-carboxamide

: 149452-44-8
4-(4-trifluoromethylbenzoyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium; iodine / tetrahydrofuran / 20 °C / Reflux

2: hydrogenchloride / water / 4 h / Reflux

With hydrogenchloride; iodine; magnesium; In tetrahydrofuran; water;
DOI:10.1039/c5ra04714e