(1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol

Base Information

Chemical Name:(1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol
CAS No.:147725-63-1
Molecular Formula:C₁₈H₃₆O₂Si
Molecular Weight:312.568
Hs Code.:
Mol file:147725-63-1.mol

Synonyms:(1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol

Suppliers and Price of (1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol

Chemical Property:

Boiling Point:351.8±15.0 °C(Predicted)
PKA:15.06±0.20(Predicted)
PSA：29.46000
Density:0.94±0.1 g/cm3(Predicted)
LogP:4.97400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol

There total 18 articles about (1R)-1-((1S,3aR,7aR)-4-(tert-butyldiMethylsilyloxy)-7a-Methyloctahydro-1H-inden-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: Toluene-4-sulfonic acid (S)-2-[(1S,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-2-hydroxy-ethyl ester

: 147725-63-1
(8β,20R)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 4h;
DOI:10.1055/s-2005-869895

Reference yield: 72.0%

: 140659-43-4
[1S-(1β,4β,7aβ)]-[1R-(3aα)]-octahydro-1-acetyl-4-[(tert-butyldimethylsilyl)oxy]-7a-methyl-1H-indene

: 147725-62-0
(20S)-De-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregnan-20-ol

: 147725-63-1
(8β,20R)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.5h;
DOI:10.1021/jo020022z

Reference yield:

: 864359-48-8
(1R,3aR,4S,7aS)-4-(tert-Butyl-dimethyl-silanyloxy)-1-ethynyl-7a-methyl-octahydro-inden-1-ol

: 147725-63-1
(8β,20R)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / pyridine; DMAP / 216 h / 20 °C

2: 63 percent / H₂O / PdCl₂(CH₃CN)2 / tetrahydrofuran / 3 h / 20 °C

3: 90 percent / DBU / ethyl acetate / 23 h / 50 °C

4: 89 percent / CeCl₃*7H₂O; NaHB₄ / methanol / 3.5 h / 0 - 20 °C

5: 80 percent / H₂ / Pd/C / ethyl acetate / 25 h / 20 °C

6: 55 percent / pyridine / 17 h / 0 °C

7: 80 percent / LiAlH₄ / diethyl ether / 4 h / 0 - 20 °C

With pyridine; dmap; lithium aluminium tetrahydride; cerium(III) chloride; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate;
DOI:10.1055/s-2005-869895