(1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol

Base Information

Chemical Name:(1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol
CAS No.:147725-62-0
Molecular Formula:C18H36O2Si
Molecular Weight:312.56
Hs Code.:
Mol file:147725-62-0.mol

Synonyms:(1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol;(8β,20S)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol;(8beta,20S)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol;(20S)-De-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregnan-20-ol;(S)-1-[(1S,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethanol;(20S)-des-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregnan-20-ol;(1S)-1-((1S,3aR,4S,7aR)-4-{[tert-butyl(dimethyl)silyl]oxy}-7a-methyloctahydro-1H-inden-1-yl)ethanol;

Suppliers and Price of (1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of (1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol

Chemical Property:

Boiling Point:351.8±15.0 °C(Predicted)
PKA:15.06±0.20(Predicted)
PSA：29.46000
Density:0.94±0.1 g/cm3(Predicted)
LogP:4.97400

Purity/Quality:: 99.0% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol

There total 11 articles about (1S)-1-((1S,3aR,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 502687-68-5
(Z)-des-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregn-17(20)-ene

: 147725-62-0
(20S)-De-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregnan-20-ol

Guidance literature:: (Z)-des-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregn-17(20)-ene; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 45 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 72.0%

: 140659-43-4
[1S-(1β,4β,7aβ)]-[1R-(3aα)]-octahydro-1-acetyl-4-[(tert-butyldimethylsilyl)oxy]-7a-methyl-1H-indene

: 147725-62-0
(20S)-De-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregnan-20-ol

: 147725-63-1
(8β,20R)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.5h;
DOI:10.1021/jo020022z

Reference yield:

: 147725-63-1
(8β,20R)-8-[(tert-butyldimethylsilyl)oxy]des-A,B-pregnan-20-ol

: 147725-62-0
(20S)-De-A,B-8β-[(tert-butyldimethylsilyl)oxy]pregnan-20-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / POCl₃ / pyridine / 0 - 5 °C

2.1: BH₃*THF / tetrahydrofuran / 2.5 h / 20 °C

2.2: 77 percent / 30percent aq. H₂O₂ / H₂O / 2 h / 0 °C

With borane-THF; trichlorophosphate; In tetrahydrofuran; pyridine;
DOI:10.1021/jo026061s