(1R,2S)-2-MethylcyclohexanaMine

Base Information

• Chemical Name: (1R,2S)-2-MethylcyclohexanaMine
• CAS No.: 79389-37-0
• Molecular Formula: C7H15N
• Molecular Weight: 113.203
• Mol file: 79389-37-0.mol

Synonyms:(1R,2S)-2-Methyl-cyclohexylamine;Cyclohexanamine, 2-methyl-, (1R,2S)-

Chemical Property of (1R,2S)-2-MethylcyclohexanaMine

Chemical Property:

• PSA: 26.02000
• LogP: 2.22410
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(1R,2S)-2-Methyl-cyclohexylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2S)-2-MethylcyclohexanaMine

There total 9 articles about (1R,2S)-2-MethylcyclohexanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(αR,1R,2S)-(+)-cis-2-Methyl-N-(1-phenylethyl)cyclohexanamin (116837-34-4) → (1R,2S)-(+)-cis-2-Methyl-cyclohexanamin (79389-37-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In acetic acid; at 50 ℃; for 19h; under 2327.23 Torr;

Reference yield:

2-(cis-2-methylcyclohexyl)-1H-isoindole-1,3(2H)-dione (2133-66-6,2133-67-7,92646-69-0) → (1R,2S)-(+)-cis-2-Methyl-cyclohexanamin (79389-37-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 85 ℃; for 3h;

DOI:10.1002/anie.202106716

Reference yield:

2-Methylcyclohexanone (583-60-8) → (1R,2R)-2-methyl-1-cyclohexylamine (931-11-3) + (1R,2S)-(+)-cis-2-Methyl-cyclohexanamin (79389-37-0) + (1S,2R)-(-)-cis-2-Methyl-cyclohexanamin (79389-36-9) + (1S,2S)-2-methyl-1-cyclohexylamine (29569-76-4)

Guidance literature:

2-Methylcyclohexanone; With [((R)-tol-binap)RuCl₂(DMF)x]; ammonium formate; In methanol; at 85 ℃; for 20h;

With hydrogenchloride; In ethanol; for 1h; Title compound not separated from byproducts; Heating;

DOI:10.1002/anie.200352503

upstream raw materials:

2-Methylcyclohexanone

(1R_.E)-N-(2-methylcyclohexylidene)-1-phenylethanamine

(αR,1R,2S)-(+)-cis-2-Methyl-N-(1-phenylethyl)cyclohexanamin

(S)-2-methylcyclohexanone

Downstream raw materials:

4,6-dimethyl-N-((1R,2S)-2-methylcyclohexyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

1,4,6-trimethyl-N-((1R,2S)-2-methylcyclohexyl)-1H-indole-2-carboxamide

2-{[(E)-(1R,2S)-2-Methyl-cyclohexylimino]-methyl}-phenol