AG-120

Base Information

Chemical Name:AG-120
CAS No.:1448346-63-1
Molecular Formula:C28H22ClF3N6O3
Molecular Weight:582.96
Hs Code.:
Mol file:1448346-63-1.mol

Synonyms:AG-120;AG-120 racemic;AG-120 Ivosidenib;Ivosidenib (RG-120);1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide;(2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide;Ivosidenib (RG-120 racemic)

Suppliers and Price of AG-120

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AG-120
25mg
$ 420.00

TRC
AG-120
50mg
$ 825.00

Chemenu
(2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide 95%+
250mg
$ 888.00

AK Scientific
AG-120
250mg
$ 1268.00

AK Scientific
AG-120
100mg
$ 664.00

AK Scientific
AG-120
1mg
$ 95.00

Activate Scientific
AG-120 98%
100 mg
$ 758.00

Activate Scientific
AG-120 98%
25 mg
$ 530.00

Activate Scientific
AG-120 98%
5 mg
$ 111.00

Total 22 raw suppliers

Chemical Property of AG-120

Chemical Property:

Boiling Point:854.3±65.0 °C(Predicted)
PKA:11.58±0.40(Predicted)
PSA：119.29000
Density:1.51±0.1 g/cm3(Predicted)
LogP:4.78048

Purity/Quality:

99%, ^*data from raw suppliers

AG-120 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses AG-120 is an intermediate in the preparation of oxoazacyclecarboxamides as anticancer agents.

Technology Process of AG-120

There total 9 articles about AG-120 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2070009-31-1
(2S)-N-{(1R)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

: 1448346-63-1,2070009-31-1
(2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 25 - 45 ℃;

Reference yield:

: 10386-27-3
2-bromoisonicotinonitrile

: (S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

: 1448346-63-1,2070009-31-1
(2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 25 - 100 ℃; for 2h;

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: (S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

: 1448346-63-1,2070009-31-1
(2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In toluene; Reflux; Inert atmosphere;