Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

Base Information

Chemical Name:Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate
CAS No.:333780-76-0
Molecular Formula:C11H9F2IO3
Molecular Weight:354.092
Hs Code.:
DSSTox Substance ID:DTXSID00477253
Wikidata:Q82309620

Synonyms:ETHYL 3-(2,3-DIFLUORO-5-IODOPHENYL)-3-OXOPROPANOATE;333780-76-0;SCHEMBL6414965;DTXSID00477253;RWYDSVFXWPPIQD-UHFFFAOYSA-N;FT-0729189

Suppliers and Price of Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:353.95645
Heavy Atom Count:17
Complexity:298

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C1=C(C(=CC(=C1)I)F)F

Technology Process of Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

There total 4 articles about Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: ethyltrimethylsilyl malonate

: 530-62-1
1,1'-carbonyldiimidazole

: 333780-74-8
2,3-difluoro-5-iodobenzoic acid

: 333780-76-0
Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

Guidance literature:: With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

Reference yield:

: 6148-64-7
ethyl potassium malonate

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 501433-05-2
2,3-difluoro-4-iodobenzoic acid

: 333780-76-0
Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

Guidance literature:: With dmap; chloro-trimethyl-silane; In tetrahydrofuran; ethyl acetate; 1,1'-carbonyldiimidazole; acetonitrile;

Reference yield:

: 6148-64-7
ethyl potassium malonate

: 333780-76-0
Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 18h;

ethyl potassium malonate; With chloro-trimethyl-silane; In acetonitrile; at 20 ℃; for 18h;

more than 3 stages;