ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate

Base Information

Chemical Name:ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate
CAS No.:449184-15-0
Molecular Formula:C₁₄H₁₄F₂INO₄
Molecular Weight:425.171
Hs Code.:

Synonyms:ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate

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Technology Process of ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate

There total 2 articles about ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 141-43-5
ethanolamine

: 449184-15-0
ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate

Guidance literature:: 2,3-difluoro-5-iodobenzoic acid; With thionyl chloride; N,N-dimethyl-formamide; for 3h; Heating / reflux;

ethyl 3-(dimethylamino)acrylate; With triethylamine; In tetrahydrofuran; at 50 ℃; for 2.5h;

ethanolamine; In tetrahydrofuran; at 40 ℃; for 1h;

Reference yield:

: 333780-76-0
Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate

: 141-43-5
ethanolamine

: 449184-15-0
ethyl (E, Z)-2-(2,3-difluoro-5-iodobenzoyl)-3-[(2-hydroxyethyl)amino]-2-propenoate

Guidance literature:: Ethyl 3-(2,3-difluoro-5-iodophenyl)-3-oxopropanoate; With orthoformic acid triethyl ester; In acetic anhydride; for 3h; Heating / reflux;

ethanolamine; In ethanol; for 18h;