8-Iodoisoquinoline

Base Information

• Chemical Name: 8-Iodoisoquinoline
• CAS No.: 1131605-27-0
• Molecular Formula: C9H6IN
• Molecular Weight: 255.06
• Mol file: 1131605-27-0.mol

Synonyms:8-Iodoisoquinoline

Chemical Property of 8-Iodoisoquinoline

Chemical Property:

• Boiling Point: 336.8±15.0 °C(Predicted)
• PKA: 4.66±0.23(Predicted)
• PSA: 12.89000
• Density: 1.837±0.06 g/cm3(Predicted)
• LogP: 2.83940
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98.5% ^*data from raw suppliers

8-Iodoisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Iodoisoquinoline

There total 2 articles about 8-Iodoisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

8-aminoisoquinoline (23687-27-6) → 8-iodoisoquinoline (1131605-27-0)

Guidance literature:

8-aminoisoquinoline; With hydrogenchloride; sodium nitrite; In water; for 0.25h; Cooling with ice;

With potassium iodide; In water; at 100 ℃; for 3h;

DOI:10.1002/chem.201502502

Reference yield: 60.0%

8-aminoisoquinoline (23687-27-6) + potassium iodide (7681-11-0) → 8-iodoisoquinoline (1131605-27-0)

Guidance literature:

8-aminoisoquinoline; With hydrogenchloride; sodium nitrite; In water; at -5 ℃; for 0.25h;

potassium iodide; In water; at 100 ℃; for 3h;

DOI:10.1002/chem.201203264

Reference yield: 13.0%

8-iodoisoquinoline (1131605-27-0) + 3-(4-((trimethylsilyl)ethynyl)phenyl)pyridine → C22H14N2

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.202106721

upstream raw materials:

8-aminoisoquinoline

potassium iodide

Refernces

• 1、 Vinueza, Nelson R.,Jankiewicz, Bart?omiej J.,Gallardo, Vanessa A.,Nash, John J.,Kentt?maa, Hilkka I.. "Effects of hydrogen bonding on the gas-phase reactivity of didehydroisoquinolinium cation isomers". . p. 21567 - 21572. Retrieved 2018.