URMC-099

Base Information

Chemical Name:URMC-099
CAS No.:1229582-33-5
Molecular Formula:C27H27N5
Molecular Weight:421.545
Hs Code.:2933998090
Mol file:1229582-33-5.mol

Synonyms:URMC-099;3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine;3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine URMC-099

Suppliers and Price of URMC-099

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
URMC-099
1mg
$ 105.00

Medical Isotopes, Inc.
URMC-099
25 mg
$ 925.00

DC Chemicals
URMC-099 >98%
100 mg
$ 500.00

ChemScene
URMC-099 99.90%
50mg
$ 270.00

ChemScene
URMC-099 99.90%
100mg
$ 450.00

ChemScene
URMC-099 99.90%
10mg
$ 90.00

ChemScene
URMC-099 99.90%
5mg
$ 60.00

Chemenu
3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine 95%+
10mg
$ 211.00

Cayman Chemical
URMC-099 ≥95%
10mg
$ 208.00

Cayman Chemical
URMC-099 ≥95%
1mg
$ 26.00

Total 23 raw suppliers

Chemical Property of URMC-099

Chemical Property:

PKA:13.49±0.40(Predicted)
PSA：50.95000
Density:1.256±0.06 g/cm3(Predicted)
LogP:5.00140
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (>25 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

URMC-099 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description URMC-099 (1229582-33-5) is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid-β degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
Uses URMC-099 is an orally bioavailable MLK3 inhibitor used in the treatment of Parkinson’s disease and HIV-1 associated neurocognitive disorders.

Technology Process of URMC-099

There total 14 articles about URMC-099 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: tert-butyl 3-iodo-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 144104-59-6
1H-indole-5-boronic acid

: 1229582-33-5
3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

Reference yield: 34.0%

: 1351477-60-5
3-iodo-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

: 144104-59-6
1H-indole-5-boronic acid

: 1229582-33-5
3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 3-iodo-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 1H-indole-5-boronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 70 ℃; for 8h; Inert atmosphere;

With potassium carbonate; In methanol; water; at 60 ℃; for 6h;
DOI:10.1016/j.bmcl.2020.127749

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1229583-72-5
4-(3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzaldehyde

: 1229582-33-5
3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 1-methyl-piperazine; 4-(3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In methanol; acetone; at 65 ℃; for 0.5h;