PF-06282999

Base Information

Chemical Name:PF-06282999
CAS No.:1435467-37-0
Molecular Formula:C13H12ClN3O3S
Molecular Weight:325.77
Hs Code.:
Mol file:1435467-37-0.mol

Synonyms:PF-06282999;PF-06282999 (Free base)

Suppliers and Price of PF-06282999

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
PF-06282999 ≥98% (HPLC)
5mg
$ 85.10

DC Chemicals
PF-06282999 >98%
1 g
$ 1700.00

DC Chemicals
PF-06282999 >98%
100 mg
$ 500.00

Cayman Chemical
PF-06282999
25mg
$ 306.00

Cayman Chemical
PF-06282999
10mg
$ 140.00

Cayman Chemical
PF-06282999
5mg
$ 79.00

Cayman Chemical
PF-06282999
1mg
$ 35.00

AK Scientific
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
25mg
$ 513.00

Total 14 raw suppliers

Chemical Property of PF-06282999

Chemical Property:

PKA:6.85±0.40(Predicted)
PSA：122.20000
Density:1.52±0.1 g/cm3(Predicted)
LogP:2.42050
Storage Temp.:room temp

Purity/Quality:

99%, ^*data from raw suppliers

PF-06282999 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of PF-06282999

There total 3 articles about PF-06282999 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 2290-65-5
trimethylsilyl isothiocyanate

: 1435472-76-6
(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

: 1435467-37-0
2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl) acetamide

Guidance literature:: trimethylsilyl isothiocyanate; (Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate; With acetic acid butyl ester; for 15h; Reflux;

With sodium hydroxide; at 30 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.5b00963

Reference yield:

: 104029-20-1
ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate

: 1435467-37-0
2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl) acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 1 h / 65 °C

1.2: 16 h / 50 °C / Reflux

2.1: acetic acid butyl ester / 15 h / Reflux

With sodium methylate; In methanol; acetic acid butyl ester;

Reference yield:

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 1435467-37-0
2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl) acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium ethylate / tetrahydrofuran / 4 h / 45 °C

1.2: 23 h / 20 - 45 °C

2.1: sodium methylate / methanol / 1 h / 65 °C

2.2: 16 h / 50 °C / Reflux

3.1: acetic acid butyl ester / 15 h / Reflux

With sodium methylate; magnesium ethylate; In tetrahydrofuran; methanol; acetic acid butyl ester;