(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Base Information

Chemical Name:(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate
CAS No.:1435472-76-6
Molecular Formula:C₁₄H₁₇ClN₂O₄
Molecular Weight:312.753
Hs Code.:

Synonyms:(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

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Chemical Property of (Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Chemical Property:

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Technology Process of (Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

There total 2 articles about (Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 104029-20-1
ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate

: 1668-10-6
glycinamide hydrochloride

: 1435472-76-6
(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Guidance literature:: glycinamide hydrochloride; With sodium methylate; In methanol; at 65 ℃; for 1h;

ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate; With acetic acid; at 50 ℃; for 16h;
DOI:10.1021/acs.jmedchem.5b00963

Reference yield:

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 1435472-76-6
(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium ethylate / tetrahydrofuran / 4 h / 45 °C

1.2: 23 h / 20 - 45 °C

2.1: sodium methylate / methanol / 1 h / 65 °C

2.2: 16 h / 50 °C / Reflux

With sodium methylate; magnesium ethylate; In tetrahydrofuran; methanol;

Reference yield: 53.0%

: 2290-65-5
trimethylsilyl isothiocyanate

: 1435472-76-6
(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

: 1435467-37-0
2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl) acetamide

Guidance literature:: trimethylsilyl isothiocyanate; (Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate; With acetic acid butyl ester; for 15h; Reflux;

With sodium hydroxide; at 30 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.5b00963