1-[3-Amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one

Base Information

• Chemical Name: 1-[3-Amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one
• CAS No.: 285980-95-2
• Molecular Formula: C₁₄H₉F₃N₂OS₂
• Molecular Weight: 342.365
• Hs Code.: 2934999090
• European Community (EC) Number: 668-555-7
• DSSTox Substance ID: DTXSID50349794
• Wikidata: Q82125267
• ChEMBL ID: CHEMBL1423165
• Mol file: 285980-95-2.mol

Synonyms:285980-95-2;1-[3-amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one;MLS000080359;1-[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethanone;SMR000037404;1-[3-amino-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethanone;1-(3-Amino-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)ethanone;1-[3-amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethanone;regid860525;Maybridge1_005981;cid_661810;CHEMBL1423165;SCHEMBL12562430;BDBM52119;HMS558H19;DTXSID50349794;HMS2182M03;CCG-1523;MFCD00124737;STK166565;AKOS002192794;FT-0755741;VU0214803-8;SR-01000599930-2;1-[3-amino-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one;1-[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]ethanone;1-[3-azanyl-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethanone

Chemical Property of 1-[3-Amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one

Chemical Property:

• Vapor Pressure: 1.81E-10mmHg at 25°C
• Melting Point: 171 °C
• Boiling Point: 508.7°C at 760 mmHg
• Flash Point: 261.5°C
• PSA: 112.46000
• Density: 1.499g/cm³
• LogP: 5.40960
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 342.01083975
• Heavy Atom Count: 22
• Complexity: 448

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-AMINO-6-THIOPHEN-2-YL-4-TRIFLUOROMETHYL-THIENO[2,3-B]PYRIDIN-2-YL)-ETHANONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C2=C(S1)N=C(C=C2C(F)(F)F)C3=CC=CS3)N

Technology Process of 1-[3-Amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one

There total 4 articles about 1-[3-Amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(trifluoromethyl)-1,2-dihydro-6-(thiophen-2-yl)-2-thioxopyridine-3-carbonitrile (104960-50-1) + chloroacetone (78-95-5) → 2-acetyl-3-amino-6-(2'-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine (285980-95-2)

Guidance literature:

With sodium acetate; In ethanol; for 4h; Heating;

Reference yield: 80.0%

2-(2-oxopropylthio)-4-(trifluoromethyl)-6-(thiophen-2-yl)pyridine-3-carbonitrile (332869-24-6) → 2-acetyl-3-amino-6-(2'-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine (285980-95-2)

Guidance literature:

With sodium ethanolate; for 3h; Reflux;

DOI:10.1080/17415993.2011.628994

Reference yield:

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione (326-91-0) → 2-acetyl-3-amino-6-(2'-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine (285980-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NEt₃ / ethanol / 2 h / Heating

2: 82 percent / NaOAc*3H₂O / ethanol / 4 h / Heating

With sodium acetate; triethylamine; In ethanol;

upstream raw materials:

4-(trifluoromethyl)-1,2-dihydro-6-(thiophen-2-yl)-2-thioxopyridine-3-carbonitrile

chloroacetone

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

2-(2-oxopropylthio)-4-(trifluoromethyl)-6-(thiophen-2-yl)pyridine-3-carbonitrile